The effectiveness of empirical antibiotics treatment in neonatal sepsis: a retrospective study

Abdulwahab Alqarni; Naji Alsulami; Khalid Alshamy

doi:10.24911/IJMDC.51-1683939427

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Original Article

Online Publishing Date:
22 / 06 / 2023

IJMDC. 2023; 7(10): 1320-1324

doi: 10.24911/IJMDC.51-1683939427

The effectiveness of empirical antibiotics treatment in neonatal sepsis: a retrospective study

Abdulwahab Alqarni, Naji Alsulami, Khalid Alshamy.

Abstract
Objective: This study aimed to investigate the effectiveness of empirical antibiotics in neonatal sepsis at Maternity and Children Hospital, Makkah, Saudi Arabia.
Methods: This retrospective study was conducted among neonates at the neonatal intensive care unit of the Maternity and Children Hospital between the period from November 2021 to January 2022. The collected data included demographics and clinical data of neonates, antibiotic administrated, blood culture results, white blood cells (WBCs) count, and C-reactive protein (CRP) before and after antibiotic administration.
Results: The data of 164 neonates were included with the mean age of 17.5 ± 7.8 days. There was a male dominancy (51.8%), and 43.3% had normal body weight. Around 14.6% positive cultures were found with dominancy of coagulase-negative (COG -ve) Staphylococcus (4.9%). Empirical antibiotics revealed significant improvement in WBCs (p = 0.002) and CRP (p = 0.000).
Conclusion: The most causative agents of neonatal sepsis were COG −ve Staphylococcus and Escherichia coli. Empirical therapy was effective in improving the laboratory markers associated with neonatal sepsis.

Key words: Effectiveness, sepsis, neonatal, treatment, empirical antibiotics.

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Pubmed Style

Alqarni A, Alsulami N, Alshamy K. The effectiveness of empirical antibiotics treatment in neonatal sepsis: a retrospective study. IJMDC. 2023; 7(10): 1320-1324. doi:10.24911/IJMDC.51-1683939427

Web Style

Alqarni A, Alsulami N, Alshamy K. The effectiveness of empirical antibiotics treatment in neonatal sepsis: a retrospective study. https://www.ijmdc.com/?mno=153120 [Access: May 12, 2024]. doi:10.24911/IJMDC.51-1683939427

AMA (American Medical Association) Style

Alqarni A, Alsulami N, Alshamy K. The effectiveness of empirical antibiotics treatment in neonatal sepsis: a retrospective study. IJMDC. 2023; 7(10): 1320-1324. doi:10.24911/IJMDC.51-1683939427

Vancouver/ICMJE Style

Alqarni A, Alsulami N, Alshamy K. The effectiveness of empirical antibiotics treatment in neonatal sepsis: a retrospective study. IJMDC. (2023), [cited May 12, 2024]; 7(10): 1320-1324. doi:10.24911/IJMDC.51-1683939427

Harvard Style

Alqarni, A., Alsulami, . N. & Alshamy, . K. (2023) The effectiveness of empirical antibiotics treatment in neonatal sepsis: a retrospective study. IJMDC, 7 (10), 1320-1324. doi:10.24911/IJMDC.51-1683939427

Turabian Style

Alqarni, Abdulwahab, Naji Alsulami, and Khalid Alshamy. 2023. The effectiveness of empirical antibiotics treatment in neonatal sepsis: a retrospective study. International Journal of Medicine in Developing Countries, 7 (10), 1320-1324. doi:10.24911/IJMDC.51-1683939427

Chicago Style

Alqarni, Abdulwahab, Naji Alsulami, and Khalid Alshamy. "The effectiveness of empirical antibiotics treatment in neonatal sepsis: a retrospective study." International Journal of Medicine in Developing Countries 7 (2023), 1320-1324. doi:10.24911/IJMDC.51-1683939427

MLA (The Modern Language Association) Style

Alqarni, Abdulwahab, Naji Alsulami, and Khalid Alshamy. "The effectiveness of empirical antibiotics treatment in neonatal sepsis: a retrospective study." International Journal of Medicine in Developing Countries 7.10 (2023), 1320-1324. Print. doi:10.24911/IJMDC.51-1683939427

APA (American Psychological Association) Style

Alqarni, A., Alsulami, . N. & Alshamy, . K. (2023) The effectiveness of empirical antibiotics treatment in neonatal sepsis: a retrospective study. International Journal of Medicine in Developing Countries, 7 (10), 1320-1324. doi:10.24911/IJMDC.51-1683939427

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