Role of premarital screening program in detection of hemoglobinopathies at Al Baha, Saudi Arabia

Abuobaida E. E. Abukhelaif; Mujib Mesfer M. Alzahrani; Abdulrahman Salem F. Alghamdi; Khalid Ali S. Alzahrani; Abdulrhman Saleh A. Alzhrani

doi:10.24911/IJMDC.51-1692375692

2024, Vol: 8, Issue: 5

8 / 5Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Original Article

Online Publishing Date:
23 / 09 / 2023

IJMDC. 2023; 7(12): 1660-1665

doi: 10.24911/IJMDC.51-1692375692

Role of premarital screening program in detection of hemoglobinopathies at Al Baha, Saudi Arabia

Abuobaida E. E. Abukhelaif, Mujib Mesfer M. Alzahrani, Abdulrahman Salem F. Alghamdi, Khalid Ali S. Alzahrani, Abdulrhman Saleh A. Alzhrani.

Abstract
Background: Hemoglobinopathies are prevalent in Saudi Arabia. The use of high-performance liquid chromatography (HPLC) for screening of these disorders has recently been undertaken. This study was conducted to estimate the prevalence of hemoglobinopathies and evaluate the role of premarital screening centers among residents of Al Baha province, Saudi Arabia.
Methods: This retrospective cohort study utilized the laboratory reports of couples attending the premarital screening centers for the screening and confirmation of hemoglobinopathies in Al Baha province, Saudi Arabia. We obtained data from four hospitals and three primary healthcare centers authorized to perform these screening tests.
Results: The current study screened and analyzed a total of 2,165 reports for suspected hemoglobinopathies. Only 121 (5.6%) reports showed abnormal hemoglobin (Hb) patterns, among which the sickle cell trait was the most common, representing 59.5% (72/121) of the reported cases. This was followed by the β-thalassemia trait, Hb Lepore, sickle cell disease, and β-thalassemia major, accounting for 32.2% (39/121), 3.3% (4/121), 2.5% (3/121), and 2.5% (3/121), respectively.
Conclusion: Sickle cell and β-thalassemia traits are the major hemoglobinopathies in Al Baha, Saudi Arabia. Premarital screening is an invaluable measure to prevent childbirth with severe Hb disorders. The use of HPLC in the screening process provides a rapid, reliable procedure for the identification of various Hb fractions.

Key words: Al Baha; Saudi Arabia; Hemoglobinopathy; Screening; Hemoglobin Variant; High Performance Liquid Chromatography.

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Abuobaida E. E. Abukhelaif Articles by Mujib Mesfer M. Alzahrani Articles by Abdulrahman Salem F. Alghamdi Articles by Khalid Ali S. Alzahrani Articles by Abdulrhman Saleh A. Alzhrani
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Abukhelaif AEE, Alzahrani MMM, Alghamdi ASF, Alzahrani KAS, Alzhrani ASA. Role of premarital screening program in detection of hemoglobinopathies at Al Baha, Saudi Arabia. IJMDC. 2023; 7(12): 1660-1665. doi:10.24911/IJMDC.51-1692375692

Web Style

Abukhelaif AEE, Alzahrani MMM, Alghamdi ASF, Alzahrani KAS, Alzhrani ASA. Role of premarital screening program in detection of hemoglobinopathies at Al Baha, Saudi Arabia. https://www.ijmdc.com/?mno=165962 [Access: May 12, 2024]. doi:10.24911/IJMDC.51-1692375692

AMA (American Medical Association) Style

Abukhelaif AEE, Alzahrani MMM, Alghamdi ASF, Alzahrani KAS, Alzhrani ASA. Role of premarital screening program in detection of hemoglobinopathies at Al Baha, Saudi Arabia. IJMDC. 2023; 7(12): 1660-1665. doi:10.24911/IJMDC.51-1692375692

Vancouver/ICMJE Style

Abukhelaif AEE, Alzahrani MMM, Alghamdi ASF, Alzahrani KAS, Alzhrani ASA. Role of premarital screening program in detection of hemoglobinopathies at Al Baha, Saudi Arabia. IJMDC. (2023), [cited May 12, 2024]; 7(12): 1660-1665. doi:10.24911/IJMDC.51-1692375692

Harvard Style

Abukhelaif, A. E. E., Alzahrani, . M. M. M., Alghamdi, . A. S. F., Alzahrani, . K. A. S. & Alzhrani, . A. S. A. (2023) Role of premarital screening program in detection of hemoglobinopathies at Al Baha, Saudi Arabia. IJMDC, 7 (12), 1660-1665. doi:10.24911/IJMDC.51-1692375692

Turabian Style

Abukhelaif, Abuobaida E. E., Mujib Mesfer M. Alzahrani, Abdulrahman Salem F. Alghamdi, Khalid Ali S. Alzahrani, and Abdulrhman Saleh A. Alzhrani. 2023. Role of premarital screening program in detection of hemoglobinopathies at Al Baha, Saudi Arabia. International Journal of Medicine in Developing Countries, 7 (12), 1660-1665. doi:10.24911/IJMDC.51-1692375692

Chicago Style

Abukhelaif, Abuobaida E. E., Mujib Mesfer M. Alzahrani, Abdulrahman Salem F. Alghamdi, Khalid Ali S. Alzahrani, and Abdulrhman Saleh A. Alzhrani. "Role of premarital screening program in detection of hemoglobinopathies at Al Baha, Saudi Arabia." International Journal of Medicine in Developing Countries 7 (2023), 1660-1665. doi:10.24911/IJMDC.51-1692375692

MLA (The Modern Language Association) Style

Abukhelaif, Abuobaida E. E., Mujib Mesfer M. Alzahrani, Abdulrahman Salem F. Alghamdi, Khalid Ali S. Alzahrani, and Abdulrhman Saleh A. Alzhrani. "Role of premarital screening program in detection of hemoglobinopathies at Al Baha, Saudi Arabia." International Journal of Medicine in Developing Countries 7.12 (2023), 1660-1665. Print. doi:10.24911/IJMDC.51-1692375692

APA (American Psychological Association) Style

Abukhelaif, A. E. E., Alzahrani, . M. M. M., Alghamdi, . A. S. F., Alzahrani, . K. A. S. & Alzhrani, . A. S. A. (2023) Role of premarital screening program in detection of hemoglobinopathies at Al Baha, Saudi Arabia. International Journal of Medicine in Developing Countries, 7 (12), 1660-1665. doi:10.24911/IJMDC.51-1692375692

Most Viewed Articles

Most Accessed Articles

Marginal adaptation of fixed prosthodontics
Shahad Mohammed Halawani, Sahar Amer Al-Harbi
IJMDC. 2017; 1(2): 78-84
» Abstract » doi: 10.24911/IJMDC.1.2.7

Parasites in central nervous system
Amal Ahmed Mohamed, Asmaa Mohamed Mansour
IJMDC. 2017; 1(2): 72-77
» Abstract » doi: 10.24911/IJMDC.1.2.6

Non-diabetic retinopathy: a case report
Hassan F. Alkwikbi, Nabil Mamon Abdelfattah, Haithem Mamon Abdelfattah
IJMDC. 2017; 1(1): 33-37
» Abstract » doi: 10.24911/IJMDC.1.1.6

Vitamin D deficiency among high school female students in Riyadh
Sahar Mohsen Aldhafeeri, Fatemah Ibraheem Alrawaji, Abrar Mubarak Algharbi, Alanoud Abdullah Alhessan, Ayat Sami Qabaja, Ghaleah Abdulaziz Alnassar, Ghaliah Ofayn Alsulami, Mashael Belal Alrubaian, Norah Abdulaziz Alhatim, Salehah Salih Alotaibi, Zahra Ali Alkhamees
IJMDC. 2017; 1(1): 18-23
» Abstract » doi: 10.24911/IJMDC.1.1.4

Prognosis of chronic complications of diabetes mellitus (DM) after multiple events of diabetic ketoacidosis (DKA)
Baraa Faiez Rajab, Anwar Essa Alamrim, Ali Essa Alamri
IJMDC. 2019; 3(5): 474-479
» Abstract » doi: 10.24911/IJMDC.51-1546551993

Most Downloaded

Top Downloaded Articles

Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.
Asmaa Ezz, Irene S. Gmail, Fatma Elzahraa H. Salem, Rabab Salama, Soad Nady
IJMDC. 2018; 2(January 2018): 38-46
» Abstract » doi: 10.24911/IJMDC.2.1.7

Antibiotic Resistance Crisis
Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
IJMDC. 2019; 3(6): 561-564
» Abstract » doi: 10.24911/IJMDC.51-1549060699

The knowledge of mothers about children malnutrition and associated factors
Anas Abdulrahman Aljohani, Mujahid Abdulrahman Aljohani
IJMDC. 2020; 4(1): 7-11
» Abstract » doi: 10.24911/IJMDC.51-1541620358

Knowledge and attitude of caregivers of cerebral palsy children in Riyadh city
Abdulaziz Alruwaished, Baleegh Ali, Lubna Abdullah Alhowaimil , Abaraa adullah Alhowaimil, Najd Abdullah Alhowaimil, Aminah Alessa
IJMDC. 2020; 4(1): 12-17
» Abstract » doi: 10.24911/IJMDC.51-1547833051

Most Cited Articles

Most Cited Articles

Antibiotic Resistance Crisis
Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
IJMDC. 2019; 3(6): 561-564
» Abstract » doi: 10.24911/IJMDC.51-1549060699
Cited : 34 times [Click to see citing articles]

Prevalence of depression, anxiety and stress among diabetes mellitus patients in Arar, Northern Saudi Arabia
AMohammed Elamin Mukrim, Nujud Muteb D. Alshammari, Wurud Muteb D. Alshammari, Maali Subhi T. Alshammari, Yousef Nasif R. Alshammari, Abdulaziz Sael M. Alshammari, Maisa Hamad F. Alanazi, Abdulelah Abdulrhman F. Alzammam, Muharib Mana M. Alshammari, Slwa Khaled Abu Asyah, Aseel Jamal Alzuhayri, Mushref Saeid Alshammari
IJMDC. 2019; 3(3): 229-233
» Abstract » doi: 10.24911/IJMDC.51-1542576396
Cited : 8 times [Click to see citing articles]

Knowledge, attitude, and practice of breast self-examination toward breast cancer among female students at King Saud University in Riyadh, Saudi Arabia
Abdullah Nasser Alomair, Dania Ghazi Felemban, Mohannad Sami Felemban, Jameel Abdullah Awadain, Ammar Saud Altowairqi, Nawaf Fawzan Alfawzan, Fatimah Mohammed Almazayen, Abdulrahman Jalwi Korkoman, Nawaf Saad Alrusayyis
IJMDC. 2020; 4(2): 429-434
» Abstract » doi: 10.24911/IJMDC.51-1576668182
Cited : 8 times [Click to see citing articles]

Population awareness about rheumatoid arthritis in Jazan region, Saudi Arabia
Ahmad Ali Hazzazi, Mohssen Hassen Ageeli, Ahmed Ali Muyidi, Abdulaziz Mohammad Abulgasim, Abdullah Ahmad Yateemi, Nabil Alhakami
IJMDC. 2020; 4(3): 668-675
» Abstract » doi: 10.24911/IJMDC.51-1576010943
Cited : 4 times [Click to see citing articles]

Prevalence and factors associated with depression among health care workers in National Guard Hospital in Riyadh, KSA
Noor Mohammad AlFahhad
IJMDC. 2018; 2(September 2018): 92-96
» Abstract » doi: 10.24911/IJMDC.51-1526306040
Cited : 4 times [Click to see citing articles]

About International Journal of Medicine in Developing Countries

Contact Information

How to cite this article