Eculizumab Utilization in Hemolytic Uremic Syndrome (HUS) Presenting with Acute Hemolysis

Ahmed H. Mousa; Hussein O. Taher; Ahmad W. Alyafi; Sara A. Alissawi; Israa A. Peeran; Rana A. Abbas; Mohammed M. Ashoor; Abdullah Baothman

doi:10.24911/IJMDC.51-1699878028

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Case Report

Online Publishing Date:
07 / 01 / 2024

IJMDC. 2024; 8(2): 906-911

doi: 10.24911/IJMDC.51-1699878028

Eculizumab Utilization in Hemolytic Uremic Syndrome (HUS) Presenting with Acute Hemolysis

Ahmed H. Mousa, Hussein O. Taher, Ahmad W. Alyafi, Sara A. Alissawi, Israa A. Peeran, Rana A. Abbas, Mohammed M. Ashoor, Abdullah Baothman.

Abstract
Background: Hemolytic uremic syndrome (HUS) is thrombotic microangiopathy in which microthrombi are formed, consisting mainly of platelets, which will occlude the arterioles and capillaries leading to a triad of intravascular hemolysis, thrombocytopenia, and acute kidney failure.
Case Presentation: A 2-year-old boy presented to our outpatient clinic with persistent diarrhea streaked with blood, vomiting, signs of dehydration, and an ingested throat. The complete blood count (CBC) revealed acute hemolysis with mild normocytic hypochromic anemia, anisopoikilocytosis, fragmented red blood cells, and moderate thrombocytopenia. The patient experienced a drastic course which was dramatically improved after the administration of eculizumab.
Conclusion: Eculizumab is a recombinant humanized monoclonal antibody against complement component C5; that effectively blocks the cleavage of complement factor C5 and, subsequently, the complement membrane attacks complex C5B-9.78. While on eculizumab, our patient’s kidney function improved significantly after the first dose with a creatinine of 0.56 mg/dl.

Key words: hemolytic uremic syndrome, eculizumab, PICU, pediatrics, hemolysis, case report.

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Pubmed Style

Mousa AH, Taher HO, Alyafi AW, Alissawi SA, Peeran IA, Abbas RA, Ashoor MM, Baothman A. Eculizumab Utilization in Hemolytic Uremic Syndrome (HUS) Presenting with Acute Hemolysis. IJMDC. 2024; 8(2): 906-911. doi:10.24911/IJMDC.51-1699878028

Web Style

Mousa AH, Taher HO, Alyafi AW, Alissawi SA, Peeran IA, Abbas RA, Ashoor MM, Baothman A. Eculizumab Utilization in Hemolytic Uremic Syndrome (HUS) Presenting with Acute Hemolysis. https://www.ijmdc.com/?mno=177274 [Access: May 12, 2024]. doi:10.24911/IJMDC.51-1699878028

AMA (American Medical Association) Style

Mousa AH, Taher HO, Alyafi AW, Alissawi SA, Peeran IA, Abbas RA, Ashoor MM, Baothman A. Eculizumab Utilization in Hemolytic Uremic Syndrome (HUS) Presenting with Acute Hemolysis. IJMDC. 2024; 8(2): 906-911. doi:10.24911/IJMDC.51-1699878028

Vancouver/ICMJE Style

Mousa AH, Taher HO, Alyafi AW, Alissawi SA, Peeran IA, Abbas RA, Ashoor MM, Baothman A. Eculizumab Utilization in Hemolytic Uremic Syndrome (HUS) Presenting with Acute Hemolysis. IJMDC. (2024), [cited May 12, 2024]; 8(2): 906-911. doi:10.24911/IJMDC.51-1699878028

Harvard Style

Mousa, A. H., Taher, . H. O., Alyafi, . A. W., Alissawi, . S. A., Peeran, . I. A., Abbas, . R. A., Ashoor, . M. M. & Baothman, . A. (2024) Eculizumab Utilization in Hemolytic Uremic Syndrome (HUS) Presenting with Acute Hemolysis. IJMDC, 8 (2), 906-911. doi:10.24911/IJMDC.51-1699878028

Turabian Style

Mousa, Ahmed H., Hussein O. Taher, Ahmad W. Alyafi, Sara A. Alissawi, Israa A. Peeran, Rana A. Abbas, Mohammed M. Ashoor, and Abdullah Baothman. 2024. Eculizumab Utilization in Hemolytic Uremic Syndrome (HUS) Presenting with Acute Hemolysis. International Journal of Medicine in Developing Countries, 8 (2), 906-911. doi:10.24911/IJMDC.51-1699878028

Chicago Style

Mousa, Ahmed H., Hussein O. Taher, Ahmad W. Alyafi, Sara A. Alissawi, Israa A. Peeran, Rana A. Abbas, Mohammed M. Ashoor, and Abdullah Baothman. "Eculizumab Utilization in Hemolytic Uremic Syndrome (HUS) Presenting with Acute Hemolysis." International Journal of Medicine in Developing Countries 8 (2024), 906-911. doi:10.24911/IJMDC.51-1699878028

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Mousa, A. H., Taher, . H. O., Alyafi, . A. W., Alissawi, . S. A., Peeran, . I. A., Abbas, . R. A., Ashoor, . M. M. & Baothman, . A. (2024) Eculizumab Utilization in Hemolytic Uremic Syndrome (HUS) Presenting with Acute Hemolysis. International Journal of Medicine in Developing Countries, 8 (2), 906-911. doi:10.24911/IJMDC.51-1699878028

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