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Review Article

Online Publishing Date:
20 / 12 / 2023

 


Paracetamol versus Non-Steroidal Anti-Inflammatory Drugs in Acute Pain in Trauma Management: Systemic Review

Abdulmajeed Farhan Atiah Alenazi, Abdulaziz Mohammed M. Alanazi, Dhari Atallah S. Alshammari, Abdulaziz Ahmed Q. Alanazi, Sulaiman Turki A. Alanazi, Abdulhamid Qaed A. Alenezi, Abdullah Ayidh Q. Alanazi, Rakan Awad A. Alenzi, Haneen Hameed G. Alanezi, Fahad Naif K. Alanazi, Abdulelah Mohammed M. Alanazi.


Abstract
Background: Effective pain management is essential for patient recovery and quality of life. Paracetamol (Acetaminophen) and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are commonly used analgesics, but their comparative efficacy remains debated. Objective: To systematically review and compare the efficacy of paracetamol and NSAIDs in various pain scenarios. Methods: A comprehensive search was conducted across major databases, primarily using PubMed. The search yielded studies that compared paracetamol to any NSAID in human trials. Following strict inclusion and exclusion criteria, 11 studies with 3,038 participants were finally included in the review. Results:
Paracetamol demonstrated comparable efficacy to NSAIDs in multiple scenarios such as post-trauma, post-partial Mastectomy Pain, and migraine in children. While, in certain situations like postoperative pain after Day-Case Operative Hysteroscopy, Pain Post-Total Hip Arthroplasty, and Pain during Rapid Maxillary Expansion, NSAIDs showcased superior efficacy. In some cases, however, such as renal colic, conflicting study evidence was presented. Moreover, in acute settings when administered I.V., paracetamol was slightly more effective. Finally, the combination of NSAIDs with paracetamol did not always offer enhanced analgesic effects. Conclusion: The choice between paracetamol and NSAIDs should be based on the specific clinical scenario and patient needs. While paracetamol is often seen as a safer option, NSAIDs play a vital role in pain management in certain conditions. Generally, due to its safety profile and less GIT and CVS complications, paracetamol should be preferred in pain management as first-line agent, especially in mild cases before moving to NSAIDS in more moderate to severe cases. The route of administration can also affect the analgesic's efficacy with the IV route showing higher efficacy. The findings highlight the potential for reducing opioid use by optimizing the use of non-opioids.

Key words: Paracetamol, NSAIDS, Acetaminophen, Pain Management


 
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How to Cite this Article
Pubmed Style

Alenazi AFA, Alanazi AMM, Alshammari DAS, Alanazi AAQ, Alanazi STA, Alenezi AQA, Alanazi AAQ, Alenzi RAA, Alanezi HHG, Alanazi FNK, Alanazi AMM. Paracetamol versus Non-Steroidal Anti-Inflammatory Drugs in Acute Pain in Trauma Management: Systemic Review. IJMDC. 2024; 8(1): 361-371. doi:10.24911/IJMDC.51-1700327913

Web Style

Alenazi AFA, Alanazi AMM, Alshammari DAS, Alanazi AAQ, Alanazi STA, Alenezi AQA, Alanazi AAQ, Alenzi RAA, Alanezi HHG, Alanazi FNK, Alanazi AMM. Paracetamol versus Non-Steroidal Anti-Inflammatory Drugs in Acute Pain in Trauma Management: Systemic Review. https://www.ijmdc.com/?mno=177933 [Access: May 12, 2024]. doi:10.24911/IJMDC.51-1700327913

AMA (American Medical Association) Style

Alenazi AFA, Alanazi AMM, Alshammari DAS, Alanazi AAQ, Alanazi STA, Alenezi AQA, Alanazi AAQ, Alenzi RAA, Alanezi HHG, Alanazi FNK, Alanazi AMM. Paracetamol versus Non-Steroidal Anti-Inflammatory Drugs in Acute Pain in Trauma Management: Systemic Review. IJMDC. 2024; 8(1): 361-371. doi:10.24911/IJMDC.51-1700327913


Vancouver/ICMJE Style

Alenazi AFA, Alanazi AMM, Alshammari DAS, Alanazi AAQ, Alanazi STA, Alenezi AQA, Alanazi AAQ, Alenzi RAA, Alanezi HHG, Alanazi FNK, Alanazi AMM. Paracetamol versus Non-Steroidal Anti-Inflammatory Drugs in Acute Pain in Trauma Management: Systemic Review. IJMDC. (2024), [cited May 12, 2024]; 8(1): 361-371. doi:10.24911/IJMDC.51-1700327913


Harvard Style

Alenazi, A. F. A., Alanazi, . A. M. M., Alshammari, . D. A. S., Alanazi, . A. A. Q., Alanazi, . S. T. A., Alenezi, . A. Q. A., Alanazi, . A. A. Q., Alenzi, . R. A. A., Alanezi, . H. H. G., Alanazi, . F. N. K. & Alanazi, . A. M. M. (2024) Paracetamol versus Non-Steroidal Anti-Inflammatory Drugs in Acute Pain in Trauma Management: Systemic Review. IJMDC, 8 (1), 361-371. doi:10.24911/IJMDC.51-1700327913


Turabian Style

Alenazi, Abdulmajeed Farhan Atiah, Abdulaziz Mohammed M. Alanazi, Dhari Atallah S. Alshammari, Abdulaziz Ahmed Q. Alanazi, Sulaiman Turki A. Alanazi, Abdulhamid Qaed A. Alenezi, Abdullah Ayidh Q. Alanazi, Rakan Awad A. Alenzi, Haneen Hameed G. Alanezi, Fahad Naif K. Alanazi, and Abdulelah Mohammed M. Alanazi. 2024. Paracetamol versus Non-Steroidal Anti-Inflammatory Drugs in Acute Pain in Trauma Management: Systemic Review. International Journal of Medicine in Developing Countries, 8 (1), 361-371. doi:10.24911/IJMDC.51-1700327913


Chicago Style

Alenazi, Abdulmajeed Farhan Atiah, Abdulaziz Mohammed M. Alanazi, Dhari Atallah S. Alshammari, Abdulaziz Ahmed Q. Alanazi, Sulaiman Turki A. Alanazi, Abdulhamid Qaed A. Alenezi, Abdullah Ayidh Q. Alanazi, Rakan Awad A. Alenzi, Haneen Hameed G. Alanezi, Fahad Naif K. Alanazi, and Abdulelah Mohammed M. Alanazi. "Paracetamol versus Non-Steroidal Anti-Inflammatory Drugs in Acute Pain in Trauma Management: Systemic Review." International Journal of Medicine in Developing Countries 8 (2024), 361-371. doi:10.24911/IJMDC.51-1700327913


MLA (The Modern Language Association) Style

Alenazi, Abdulmajeed Farhan Atiah, Abdulaziz Mohammed M. Alanazi, Dhari Atallah S. Alshammari, Abdulaziz Ahmed Q. Alanazi, Sulaiman Turki A. Alanazi, Abdulhamid Qaed A. Alenezi, Abdullah Ayidh Q. Alanazi, Rakan Awad A. Alenzi, Haneen Hameed G. Alanezi, Fahad Naif K. Alanazi, and Abdulelah Mohammed M. Alanazi. "Paracetamol versus Non-Steroidal Anti-Inflammatory Drugs in Acute Pain in Trauma Management: Systemic Review." International Journal of Medicine in Developing Countries 8.1 (2024), 361-371. Print. doi:10.24911/IJMDC.51-1700327913


APA (American Psychological Association) Style

Alenazi, A. F. A., Alanazi, . A. M. M., Alshammari, . D. A. S., Alanazi, . A. A. Q., Alanazi, . S. T. A., Alenezi, . A. Q. A., Alanazi, . A. A. Q., Alenzi, . R. A. A., Alanezi, . H. H. G., Alanazi, . F. N. K. & Alanazi, . A. M. M. (2024) Paracetamol versus Non-Steroidal Anti-Inflammatory Drugs in Acute Pain in Trauma Management: Systemic Review. International Journal of Medicine in Developing Countries, 8 (1), 361-371. doi:10.24911/IJMDC.51-1700327913




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