IJMDC. 2017; 1(2): 85-87

Effectiveness of apixaban in warfarin hepatotoxicity: A case report

Authors: Ali A Alaklabi, Abdullah M Alotaibi, Abdulmalik S Alotaibi, M Alessa, Hanan Abdulrahman Habeeb.

ABSTRACT

Background: Apixaban is a direct and competitive inhibitor of factor Xa. It has been shown to be effective and safe to Prevent Stroke in Atrial Fibrillation Patients. This study is a case report of warfarin-induced cholestasis that occurred one week after starting warfarin for deep venous thrombosis, in which the cholestasis improved after the offending drug was stopped but worsened after beginning apixaban. Case Presentation: We presented a case of 79-year-old woman, she was presented to the emergency depart¨ment with a chief complaint of left lower limb swelling of 3 days duration. On physical examination, her left lower limb was swollen, warm, and tender. Venous Doppler ultrasound showed extensive deep venous throm¨bosis and anticoagulation with unfractionated heparin and warfarin 7 mg initiated. Conclusion: Apixaban should be avoided in patients with warfarin-induced cholestasis.

Keywords:
Warfarin, apixaban, hepatotoxicity, anticoagulant, thrombosis, case report.


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Effectiveness of apixaban in warfarin hepatotoxicity: A case report


Authors
Ali A Alaklabi
Department of Medicine, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, Department of Pharmacy, King Abdulaziz Medical City, Riyadh, Saudi Arabia
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Abdullah M Alotaibi
Department of Medicine, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
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Abdulmalik S Alotaibi
Department of Pharmacy, King Abdulaziz Medical City, Riyadh, Saudi Arabia
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M Alessa
Department of Pharmacy, King Abdulaziz Medical City, Riyadh, Saudi Arabia
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Hanan Abdulrahman Habeeb
Department of Medicine, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
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Correspondence to:
. Department of Medicine, National Guard Health Affairs, Riyadh, Saudi Arabia.;

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Pubmed Style

Alaklabi AA, Alotaibi AM, Alotaibi AS, Alessa M, Habeeb HA. Effectiveness of apixaban in warfarin hepatotoxicity: A case report. IJMDC. 2017; 1(2): 85-87. doi:10.24911/IJMDC.1.2.8


Web Style

Alaklabi AA, Alotaibi AM, Alotaibi AS, Alessa M, Habeeb HA. Effectiveness of apixaban in warfarin hepatotoxicity: A case report. http://www.ijmdc.com/?mno=287580 [Access: October 20, 2018]. doi:10.24911/IJMDC.1.2.8


AMA (American Medical Association) Style

Alaklabi AA, Alotaibi AM, Alotaibi AS, Alessa M, Habeeb HA. Effectiveness of apixaban in warfarin hepatotoxicity: A case report. IJMDC. 2017; 1(2): 85-87. doi:10.24911/IJMDC.1.2.8


Vancouver/ICMJE Style

Alaklabi AA, Alotaibi AM, Alotaibi AS, Alessa M, Habeeb HA. Effectiveness of apixaban in warfarin hepatotoxicity: A case report. IJMDC. (2017), [cited October 20, 2018]; 1(2): 85-87. doi:10.24911/IJMDC.1.2.8


Harvard Style

Alaklabi, A. A., Alotaibi, A. M., Alotaibi, A. S., Alessa, M. & Habeeb, H. A. (2017) Effectiveness of apixaban in warfarin hepatotoxicity: A case report. IJMDC, 1 (2), 85-87. doi:10.24911/IJMDC.1.2.8


Turabian Style

Alaklabi, Ali A, Abdullah M Alotaibi, Abdulmalik S Alotaibi, M Alessa, and Hanan Abdulrahman Habeeb. 2017. Effectiveness of apixaban in warfarin hepatotoxicity: A case report. International Journal of Medicine in Developing Countries, 1 (2), 85-87. doi:10.24911/IJMDC.1.2.8


Chicago Style

Alaklabi, Ali A, Abdullah M Alotaibi, Abdulmalik S Alotaibi, M Alessa, and Hanan Abdulrahman Habeeb. "Effectiveness of apixaban in warfarin hepatotoxicity: A case report." International Journal of Medicine in Developing Countries 1 (2017), 85-87. doi:10.24911/IJMDC.1.2.8


MLA (The Modern Language Association) Style

Alaklabi, Ali A, Abdullah M Alotaibi, Abdulmalik S Alotaibi, M Alessa, and Hanan Abdulrahman Habeeb. "Effectiveness of apixaban in warfarin hepatotoxicity: A case report." International Journal of Medicine in Developing Countries 1.2 (2017), 85-87. Print. doi:10.24911/IJMDC.1.2.8


APA (American Psychological Association) Style

Alaklabi, A. A., Alotaibi, A. M., Alotaibi, A. S., Alessa, M. & Habeeb, H. A. (2017) Effectiveness of apixaban in warfarin hepatotoxicity: A case report. International Journal of Medicine in Developing Countries, 1 (2), 85-87. doi:10.24911/IJMDC.1.2.8


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