Development and validation of a questionnaire measuring the awareness of Isotretinoins teratogenic effects among women in Makkah province, Saudi Arabia

Louai A. Salah; Yara R. Elhaddad; Rawan Al-Mekhlafi; Rawabi Attiyah; Daniah Ahmed

doi:10.24911/IJMDC.51-1598445099

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Original Article
Online Published: 28 Oct 2020

IJMDC. 2020; 4(11): 1766-1770

doi: 10.24911/IJMDC.51-1598445099

Development and validation of a questionnaire measuring the awareness of Isotretinoins teratogenic effects among women in Makkah province, Saudi Arabia

Louai A. Salah, Yara R. Elhaddad, Rawan Al-mekhlafi, Rawabi Attiyah, Daniah Ahmed.

Abstract
Background: Isotretinoin, an oral vitamin A analog, is the most effective acne medication. Unfortunately, such potency comes with various side effects. This study was carried out for the development and validation of a self-administered online questionnaire on isotretinoin teratogenicity awareness among women in Makkah Province, Saudi Arabia.
Methodology: A 28-item validated self-administered online questionnaire was used in this study, from January 27, 2019 to February 25, 2020. Two pilot surveys were carried out to test the validity of the modified questionnaire, and Cronbachs alpha was found to be 0.742. The pilot surveys only included women of childbearing age (12-51 years old) in addition to being on isotretinoin treatment.
Results: Out of the total 24 responses, 22 women experienced skin, lip, and eye dryness, four experienced increased blood cholesterol level, and two did not face any side effects at all. Five patients were sexually active and 18 were not sexually active during the isotretinoin course. Higher awareness was seen for both the teratogenicity and avoidance of pregnancy aspects in the sexually active group when compared with the non-sexually active group.
Conclusion: Educating patients on proper practices should be prioritized. Overall, the questionnaire has been proven valid and reliable to be used on large-scale studies in the population of interest.

Key words: Acne, female, perception, pregnancy, Saudi Arabia, survey

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Pubmed Style

Salah LA, Elhaddad YR, Al-mekhlafi R, Attiyah R, Ahmed D. Development and validation of a questionnaire measuring the awareness of Isotretinoins teratogenic effects among women in Makkah province, Saudi Arabia. IJMDC. 2020; 4(11): 1766-1770. doi:10.24911/IJMDC.51-1598445099

Web Style

Salah LA, Elhaddad YR, Al-mekhlafi R, Attiyah R, Ahmed D. Development and validation of a questionnaire measuring the awareness of Isotretinoins teratogenic effects among women in Makkah province, Saudi Arabia. https://www.ijmdc.com/?mno=129023 [Access: October 14, 2025]. doi:10.24911/IJMDC.51-1598445099

AMA (American Medical Association) Style

Salah LA, Elhaddad YR, Al-mekhlafi R, Attiyah R, Ahmed D. Development and validation of a questionnaire measuring the awareness of Isotretinoins teratogenic effects among women in Makkah province, Saudi Arabia. IJMDC. 2020; 4(11): 1766-1770. doi:10.24911/IJMDC.51-1598445099

Vancouver/ICMJE Style

Salah LA, Elhaddad YR, Al-mekhlafi R, Attiyah R, Ahmed D. Development and validation of a questionnaire measuring the awareness of Isotretinoins teratogenic effects among women in Makkah province, Saudi Arabia. IJMDC. (2020), [cited October 14, 2025]; 4(11): 1766-1770. doi:10.24911/IJMDC.51-1598445099

Harvard Style

Salah, L. A., Elhaddad, . Y. R., Al-mekhlafi, . R., Attiyah, . R. & Ahmed, . D. (2020) Development and validation of a questionnaire measuring the awareness of Isotretinoins teratogenic effects among women in Makkah province, Saudi Arabia. IJMDC, 4 (11), 1766-1770. doi:10.24911/IJMDC.51-1598445099

Turabian Style

Salah, Louai A., Yara R. Elhaddad, Rawan Al-mekhlafi, Rawabi Attiyah, and Daniah Ahmed. 2020. Development and validation of a questionnaire measuring the awareness of Isotretinoins teratogenic effects among women in Makkah province, Saudi Arabia. International Journal of Medicine in Developing Countries, 4 (11), 1766-1770. doi:10.24911/IJMDC.51-1598445099

Chicago Style

Salah, Louai A., Yara R. Elhaddad, Rawan Al-mekhlafi, Rawabi Attiyah, and Daniah Ahmed. "Development and validation of a questionnaire measuring the awareness of Isotretinoins teratogenic effects among women in Makkah province, Saudi Arabia." International Journal of Medicine in Developing Countries 4 (2020), 1766-1770. doi:10.24911/IJMDC.51-1598445099

MLA (The Modern Language Association) Style

Salah, Louai A., Yara R. Elhaddad, Rawan Al-mekhlafi, Rawabi Attiyah, and Daniah Ahmed. "Development and validation of a questionnaire measuring the awareness of Isotretinoins teratogenic effects among women in Makkah province, Saudi Arabia." International Journal of Medicine in Developing Countries 4.11 (2020), 1766-1770. Print. doi:10.24911/IJMDC.51-1598445099

APA (American Psychological Association) Style

Salah, L. A., Elhaddad, . Y. R., Al-mekhlafi, . R., Attiyah, . R. & Ahmed, . D. (2020) Development and validation of a questionnaire measuring the awareness of Isotretinoins teratogenic effects among women in Makkah province, Saudi Arabia. International Journal of Medicine in Developing Countries, 4 (11), 1766-1770. doi:10.24911/IJMDC.51-1598445099

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