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Review Article
Online Published: 21 Oct 2020
 


Sodium-glucose cotransporter 2 inhibitor effects on cardiovascular outcomes: a short review

Ibrahim Mahmoud H Ajwah, Waleed Jamal Aloqbi, Ahmed Ebrahim Al Ansari, Nawaf Saeed Almalki, Abdulelah Hamdan Alonizei, Razan Faisal Aljohani, Omniyyah Ahmed Alnahyah, Razan Kamel Albalawi, Sultan Makki Alsharef, Abdulrahman Abdulhadi Alatawi, Afnan Mohammed Almutairi, Wedad Eid Aljthli, Amirah Naif Albalawi, Mohammed A. Alotaibi, Mohammed Abdullah Alasmari, Atheer Hammad Alatawi.


Abstract
Type 2 diabetes is a chronic and progressive disease associated with a series of complications, including major
adverse cardiovascular events. As adequate glycemic control has been proven to reduce this risk, sodium-glucose
cotransporter 2 (SGLT2) inhibitors are among the promising medications in managing patients with type
2 diabetes. The current systematic review aimed to explore the SGLT2 inhibitor effects on cardiovascular outcomes.
A filtration procedure was used to remove duplicates and irrelevant publications. The online databases such as PubMed, Google Scholar, and EBSCO were used to perform a literature search, without any date or language restrictions. We used a combination of relevant search terms “diabetes, sodium-glucose cotransporter 2 inhibitors, and cardiovascular." We independently identified publications and systematically screened titles, abstracts, and full texts of the collected publications. Among 200 articles initially selected based on the title and abstract, 197 articles were excluded. Finally, three articles were selected and included in the review. All three studies concerned about the cardiovascular safety of SGLT2 inhibitors and showed that, compared with placebo, empagliflozin, canagliflozin, and dapagliflozin safely lower blood glucose with a reduction in the major adverse cardiovascular events. Across the three trials, empagliflozin, canagliflozin, and dapagliflozin resulted in a consistent class effect on cardiovascular outcomes.

Key words: Cardiovascular events, SGLT2 inhibitor, diabetes.‎


 
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How to Cite this Article
Pubmed Style

Ajwah IMH, Aloqbi WJ, Ansari AEA, Almalki NS, Alonizei AH, Aljohani RF, Alnahyah OA, Albalawi RK, Alsharef SM, Alatawi AA, Almutairi AM, Aljthli WE, Albalawi AN, Alotaibi MA, Alasmari MA, Alatawi AH. Sodium-glucose cotransporter 2 inhibitor effects on cardiovascular outcomes: a short review. IJMDC. 2020; 4(11): 1993-1995. doi:10.24911/IJMDC.51-1599914173

Web Style

Ajwah IMH, Aloqbi WJ, Ansari AEA, Almalki NS, Alonizei AH, Aljohani RF, Alnahyah OA, Albalawi RK, Alsharef SM, Alatawi AA, Almutairi AM, Aljthli WE, Albalawi AN, Alotaibi MA, Alasmari MA, Alatawi AH. Sodium-glucose cotransporter 2 inhibitor effects on cardiovascular outcomes: a short review. https://www.ijmdc.com/?mno=134451 [Access: October 14, 2025]. doi:10.24911/IJMDC.51-1599914173

AMA (American Medical Association) Style

Ajwah IMH, Aloqbi WJ, Ansari AEA, Almalki NS, Alonizei AH, Aljohani RF, Alnahyah OA, Albalawi RK, Alsharef SM, Alatawi AA, Almutairi AM, Aljthli WE, Albalawi AN, Alotaibi MA, Alasmari MA, Alatawi AH. Sodium-glucose cotransporter 2 inhibitor effects on cardiovascular outcomes: a short review. IJMDC. 2020; 4(11): 1993-1995. doi:10.24911/IJMDC.51-1599914173


Vancouver/ICMJE Style

Ajwah IMH, Aloqbi WJ, Ansari AEA, Almalki NS, Alonizei AH, Aljohani RF, Alnahyah OA, Albalawi RK, Alsharef SM, Alatawi AA, Almutairi AM, Aljthli WE, Albalawi AN, Alotaibi MA, Alasmari MA, Alatawi AH. Sodium-glucose cotransporter 2 inhibitor effects on cardiovascular outcomes: a short review. IJMDC. (2020), [cited October 14, 2025]; 4(11): 1993-1995. doi:10.24911/IJMDC.51-1599914173


Harvard Style

Ajwah, I. M. H., Aloqbi, . W. J., Ansari, . A. E. A., Almalki, . N. S., Alonizei, . A. H., Aljohani, . R. F., Alnahyah, . O. A., Albalawi, . R. K., Alsharef, . S. M., Alatawi, . A. A., Almutairi, . A. M., Aljthli, . W. E., Albalawi, . A. N., Alotaibi, . M. A., Alasmari, . M. A. & Alatawi, . A. H. (2020) Sodium-glucose cotransporter 2 inhibitor effects on cardiovascular outcomes: a short review. IJMDC, 4 (11), 1993-1995. doi:10.24911/IJMDC.51-1599914173


Turabian Style

Ajwah, Ibrahim Mahmoud H, Waleed Jamal Aloqbi, Ahmed Ebrahim Al Ansari, Nawaf Saeed Almalki, Abdulelah Hamdan Alonizei, Razan Faisal Aljohani, Omniyyah Ahmed Alnahyah, Razan Kamel Albalawi, Sultan Makki Alsharef, Abdulrahman Abdulhadi Alatawi, Afnan Mohammed Almutairi, Wedad Eid Aljthli, Amirah Naif Albalawi, Mohammed A. Alotaibi, Mohammed Abdullah Alasmari, and Atheer Hammad Alatawi. 2020. Sodium-glucose cotransporter 2 inhibitor effects on cardiovascular outcomes: a short review. International Journal of Medicine in Developing Countries, 4 (11), 1993-1995. doi:10.24911/IJMDC.51-1599914173


Chicago Style

Ajwah, Ibrahim Mahmoud H, Waleed Jamal Aloqbi, Ahmed Ebrahim Al Ansari, Nawaf Saeed Almalki, Abdulelah Hamdan Alonizei, Razan Faisal Aljohani, Omniyyah Ahmed Alnahyah, Razan Kamel Albalawi, Sultan Makki Alsharef, Abdulrahman Abdulhadi Alatawi, Afnan Mohammed Almutairi, Wedad Eid Aljthli, Amirah Naif Albalawi, Mohammed A. Alotaibi, Mohammed Abdullah Alasmari, and Atheer Hammad Alatawi. "Sodium-glucose cotransporter 2 inhibitor effects on cardiovascular outcomes: a short review." International Journal of Medicine in Developing Countries 4 (2020), 1993-1995. doi:10.24911/IJMDC.51-1599914173


MLA (The Modern Language Association) Style

Ajwah, Ibrahim Mahmoud H, Waleed Jamal Aloqbi, Ahmed Ebrahim Al Ansari, Nawaf Saeed Almalki, Abdulelah Hamdan Alonizei, Razan Faisal Aljohani, Omniyyah Ahmed Alnahyah, Razan Kamel Albalawi, Sultan Makki Alsharef, Abdulrahman Abdulhadi Alatawi, Afnan Mohammed Almutairi, Wedad Eid Aljthli, Amirah Naif Albalawi, Mohammed A. Alotaibi, Mohammed Abdullah Alasmari, and Atheer Hammad Alatawi. "Sodium-glucose cotransporter 2 inhibitor effects on cardiovascular outcomes: a short review." International Journal of Medicine in Developing Countries 4.11 (2020), 1993-1995. Print. doi:10.24911/IJMDC.51-1599914173


APA (American Psychological Association) Style

Ajwah, I. M. H., Aloqbi, . W. J., Ansari, . A. E. A., Almalki, . N. S., Alonizei, . A. H., Aljohani, . R. F., Alnahyah, . O. A., Albalawi, . R. K., Alsharef, . S. M., Alatawi, . A. A., Almutairi, . A. M., Aljthli, . W. E., Albalawi, . A. N., Alotaibi, . M. A., Alasmari, . M. A. & Alatawi, . A. H. (2020) Sodium-glucose cotransporter 2 inhibitor effects on cardiovascular outcomes: a short review. International Journal of Medicine in Developing Countries, 4 (11), 1993-1995. doi:10.24911/IJMDC.51-1599914173




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