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Review Article
Online Published: 22 Nov 2024
 


The role of ACE inhibitors in delaying the progression of kidney disease in pediatric patients: a systematic review

Ayedh Mohammed Alkhalqi, Hussain Ahmed S. Al Rashah, Ahmed Mohseen Y. Al Rashah, Yahya Ishaq R. Ishaq, Ali Mohammed A. Al Murthimah, Ahmed Hussain A. Al Abyah, Mohammed Hadi S. Al Baalharith, Ali Mohammad H. Alyami, Al Ishaq Yousef Mohammed R.


Abstract
Chronic kidney disease (CKD) is a growing concern in children, leading to significant health complications. While angiotensin-converting enzyme (ACE) inhibitors are used in adults with CKD to slow disease progression, their effectiveness in pediatric patients remains unclear. This systematic review aimed to evaluate the existing research on the efficacy and safety of ACE inhibitors in delaying the progression of CKD in children. A systematic search of electronic databases like PubMed, MEDLINE, Science Direct, and Scopus was conducted. Two independent reviewers screened and extracted data from eligible studies. Six studies including 519 participants in total, of which 209 (40%) were females, were included in the study data. The follow-up duration ranged from 6 months to 7.75 years. ACE inhibitors decreased the albumin excretion rate in daily urine and the albumin creatinine ratio in daily urine dropped with renoprotective therapy. Management with ACE inhibitors maintained graft function in children with chronic allograft dysfunction, with enhancement of creatinine clearance in children undergoing renal transplantation. To this day, ACEIs represent the greatest known means of slowing the advancement of pediatric nephropathy and chronic non-diabetic renal disorders. Prospective comparison research and trials of combination therapy with ACEI and angiotensin receptor blocker should be promoted in children. A multicenter trial would be necessary due to the minimal number of patients.

Key words: Pediatric, chronic kidney disease (CKD), End-stage renal disease (ESRD), ACE inhibitors, glomerular filtration rate (GFR)


 
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How to Cite this Article
Pubmed Style

Alkhalqi AM, Rashah HASA, Rashah AMYA, Ishaq YIR, Murthimah AMAA, Abyah AHAA, Baalharith MHSA, Alyami AMH, R AIYM. The role of ACE inhibitors in delaying the progression of kidney disease in pediatric patients: a systematic review. IJMDC. 2024; 8(10): 2868-2873. doi:10.24911/IJMDC.51-1726928538

Web Style

Alkhalqi AM, Rashah HASA, Rashah AMYA, Ishaq YIR, Murthimah AMAA, Abyah AHAA, Baalharith MHSA, Alyami AMH, R AIYM. The role of ACE inhibitors in delaying the progression of kidney disease in pediatric patients: a systematic review. https://www.ijmdc.com/?mno=221469 [Access: March 17, 2025]. doi:10.24911/IJMDC.51-1726928538

AMA (American Medical Association) Style

Alkhalqi AM, Rashah HASA, Rashah AMYA, Ishaq YIR, Murthimah AMAA, Abyah AHAA, Baalharith MHSA, Alyami AMH, R AIYM. The role of ACE inhibitors in delaying the progression of kidney disease in pediatric patients: a systematic review. IJMDC. 2024; 8(10): 2868-2873. doi:10.24911/IJMDC.51-1726928538


Vancouver/ICMJE Style

Alkhalqi AM, Rashah HASA, Rashah AMYA, Ishaq YIR, Murthimah AMAA, Abyah AHAA, Baalharith MHSA, Alyami AMH, R AIYM. The role of ACE inhibitors in delaying the progression of kidney disease in pediatric patients: a systematic review. IJMDC. (2024), [cited March 17, 2025]; 8(10): 2868-2873. doi:10.24911/IJMDC.51-1726928538


Harvard Style

Alkhalqi, A. M., Rashah, . H. A. S. A., Rashah, . A. M. Y. A., Ishaq, . Y. I. R., Murthimah, . A. M. A. A., Abyah, . A. H. A. A., Baalharith, . M. H. S. A., Alyami, . A. M. H. & R, . A. I. Y. M. (2024) The role of ACE inhibitors in delaying the progression of kidney disease in pediatric patients: a systematic review. IJMDC, 8 (10), 2868-2873. doi:10.24911/IJMDC.51-1726928538


Turabian Style

Alkhalqi, Ayedh Mohammed, Hussain Ahmed S. Al Rashah, Ahmed Mohseen Y. Al Rashah, Yahya Ishaq R. Ishaq, Ali Mohammed A. Al Murthimah, Ahmed Hussain A. Al Abyah, Mohammed Hadi S. Al Baalharith, Ali Mohammad H. Alyami, and Al Ishaq Yousef Mohammed R. 2024. The role of ACE inhibitors in delaying the progression of kidney disease in pediatric patients: a systematic review. International Journal of Medicine in Developing Countries, 8 (10), 2868-2873. doi:10.24911/IJMDC.51-1726928538


Chicago Style

Alkhalqi, Ayedh Mohammed, Hussain Ahmed S. Al Rashah, Ahmed Mohseen Y. Al Rashah, Yahya Ishaq R. Ishaq, Ali Mohammed A. Al Murthimah, Ahmed Hussain A. Al Abyah, Mohammed Hadi S. Al Baalharith, Ali Mohammad H. Alyami, and Al Ishaq Yousef Mohammed R. "The role of ACE inhibitors in delaying the progression of kidney disease in pediatric patients: a systematic review." International Journal of Medicine in Developing Countries 8 (2024), 2868-2873. doi:10.24911/IJMDC.51-1726928538


MLA (The Modern Language Association) Style

Alkhalqi, Ayedh Mohammed, Hussain Ahmed S. Al Rashah, Ahmed Mohseen Y. Al Rashah, Yahya Ishaq R. Ishaq, Ali Mohammed A. Al Murthimah, Ahmed Hussain A. Al Abyah, Mohammed Hadi S. Al Baalharith, Ali Mohammad H. Alyami, and Al Ishaq Yousef Mohammed R. "The role of ACE inhibitors in delaying the progression of kidney disease in pediatric patients: a systematic review." International Journal of Medicine in Developing Countries 8.10 (2024), 2868-2873. Print. doi:10.24911/IJMDC.51-1726928538


APA (American Psychological Association) Style

Alkhalqi, A. M., Rashah, . H. A. S. A., Rashah, . A. M. Y. A., Ishaq, . Y. I. R., Murthimah, . A. M. A. A., Abyah, . A. H. A. A., Baalharith, . M. H. S. A., Alyami, . A. M. H. & R, . A. I. Y. M. (2024) The role of ACE inhibitors in delaying the progression of kidney disease in pediatric patients: a systematic review. International Journal of Medicine in Developing Countries, 8 (10), 2868-2873. doi:10.24911/IJMDC.51-1726928538




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