Sodium-glucose co-transporter-2 inhibitors in the management of heart failure patients: a systematic review of randomized controlled trials

Abeer A. Alomairi; Ibtihal Z. Alanazi; Zainab J. Alqurain; Alaa F. Samandar; Shahad M. Alharbi; Zainab Alkhmis; Sarah Alanazi; Rama A. Alhatlani; Ihab F. Sulaiman

doi:10.24911/IJMDC.51-1729965941

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Review Article
Online Published: 30 Dec 2024

IJMDC. 2024; 8(12): 3698-3706

doi: 10.24911/IJMDC.51-1729965941

Sodium-glucose co-transporter-2 inhibitors in the management of heart failure patients: a systematic review of randomized controlled trials

Abeer A. Alomairi, Ibtihal Z. Alanazi, Zainab J. Alqurain, Alaa F. Samandar, Shahad M. Alharbi, Zainab Alkhmis, Sarah Alanazi, Rama A. Alhatlani, Ihab F. Sulaiman.

Abstract
Sodium-glucose co-transporter 2 (SGLT-2) inhibitors, initially developed for type 2 diabetes mellitus, might also have cardioprotective properties for heart failure (HF) patients, independent of blood glucose levels. This systematic review and meta-analysis evaluated the effectiveness of SGLT-2 inhibitors in improving outcomes for HF patients, regardless of ejection fraction (EF) status or HF type. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, databases, such as Embase, Medline, and Global Health, were searched for relevant clinical studies. Nine studies were analyzed with 19,904 participants (11,155 treated with SGLT-2 inhibitors and 8,749 control patients). Results indicated significant improvements in EF and overall heart function with SGLT-2 inhibitors compared to standard care. Future well-designed studies with extended follow-up periods and diverse patient demographics are needed to fully understand the long-term effects and optimize HF management with SGLT-2 inhibitors.

Key words: Ejection fraction, heart failure, kidney function, SGLT-2 Inhibitors.

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Pubmed Style

Alomairi AA, Alanazi IZ, Alqurain ZJ, Samandar AF, Alharbi SM, Alkhmis Z, Alanazi S, Alhatlani RA, Sulaiman IF. Sodium-glucose co-transporter-2 inhibitors in the management of heart failure patients: a systematic review of randomized controlled trials. IJMDC. 2024; 8(12): 3698-3706. doi:10.24911/IJMDC.51-1729965941

Web Style

Alomairi AA, Alanazi IZ, Alqurain ZJ, Samandar AF, Alharbi SM, Alkhmis Z, Alanazi S, Alhatlani RA, Sulaiman IF. Sodium-glucose co-transporter-2 inhibitors in the management of heart failure patients: a systematic review of randomized controlled trials. https://www.ijmdc.com/?mno=226245 [Access: October 14, 2025]. doi:10.24911/IJMDC.51-1729965941

AMA (American Medical Association) Style

Alomairi AA, Alanazi IZ, Alqurain ZJ, Samandar AF, Alharbi SM, Alkhmis Z, Alanazi S, Alhatlani RA, Sulaiman IF. Sodium-glucose co-transporter-2 inhibitors in the management of heart failure patients: a systematic review of randomized controlled trials. IJMDC. 2024; 8(12): 3698-3706. doi:10.24911/IJMDC.51-1729965941

Vancouver/ICMJE Style

Alomairi AA, Alanazi IZ, Alqurain ZJ, Samandar AF, Alharbi SM, Alkhmis Z, Alanazi S, Alhatlani RA, Sulaiman IF. Sodium-glucose co-transporter-2 inhibitors in the management of heart failure patients: a systematic review of randomized controlled trials. IJMDC. (2024), [cited October 14, 2025]; 8(12): 3698-3706. doi:10.24911/IJMDC.51-1729965941

Harvard Style

Alomairi, A. A., Alanazi, . I. Z., Alqurain, . Z. J., Samandar, . A. F., Alharbi, . S. M., Alkhmis, . Z., Alanazi, . S., Alhatlani, . R. A. & Sulaiman, . I. F. (2024) Sodium-glucose co-transporter-2 inhibitors in the management of heart failure patients: a systematic review of randomized controlled trials. IJMDC, 8 (12), 3698-3706. doi:10.24911/IJMDC.51-1729965941

Turabian Style

Alomairi, Abeer A., Ibtihal Z. Alanazi, Zainab J. Alqurain, Alaa F. Samandar, Shahad M. Alharbi, Zainab Alkhmis, Sarah Alanazi, Rama A. Alhatlani, and Ihab F. Sulaiman. 2024. Sodium-glucose co-transporter-2 inhibitors in the management of heart failure patients: a systematic review of randomized controlled trials. International Journal of Medicine in Developing Countries, 8 (12), 3698-3706. doi:10.24911/IJMDC.51-1729965941

Chicago Style

Alomairi, Abeer A., Ibtihal Z. Alanazi, Zainab J. Alqurain, Alaa F. Samandar, Shahad M. Alharbi, Zainab Alkhmis, Sarah Alanazi, Rama A. Alhatlani, and Ihab F. Sulaiman. "Sodium-glucose co-transporter-2 inhibitors in the management of heart failure patients: a systematic review of randomized controlled trials." International Journal of Medicine in Developing Countries 8 (2024), 3698-3706. doi:10.24911/IJMDC.51-1729965941

MLA (The Modern Language Association) Style

Alomairi, Abeer A., Ibtihal Z. Alanazi, Zainab J. Alqurain, Alaa F. Samandar, Shahad M. Alharbi, Zainab Alkhmis, Sarah Alanazi, Rama A. Alhatlani, and Ihab F. Sulaiman. "Sodium-glucose co-transporter-2 inhibitors in the management of heart failure patients: a systematic review of randomized controlled trials." International Journal of Medicine in Developing Countries 8.12 (2024), 3698-3706. Print. doi:10.24911/IJMDC.51-1729965941

APA (American Psychological Association) Style

Alomairi, A. A., Alanazi, . I. Z., Alqurain, . Z. J., Samandar, . A. F., Alharbi, . S. M., Alkhmis, . Z., Alanazi, . S., Alhatlani, . R. A. & Sulaiman, . I. F. (2024) Sodium-glucose co-transporter-2 inhibitors in the management of heart failure patients: a systematic review of randomized controlled trials. International Journal of Medicine in Developing Countries, 8 (12), 3698-3706. doi:10.24911/IJMDC.51-1729965941

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