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Review Article
Online Published: 31 Dec 2024
 


Association between gastroesophageal reflux disease and irritable bowel syndrome: a systematic review and meta-analysis

Abdullah Alharbi, Khalid Altaleb, Mohammed Alrasheed, Faisal Almashuf, Omar Aldayhani, Abdulaziz Alhassan, Mohammad Alsultan, Abdullah Alhamoudi, Mohammed Alosaimi, Faisal Almutawa, Asma Alanazi.


Abstract
Gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) are two common gastrointestinal disorders, often presenting with overlapping symptoms. Recognizing the coexistence of GERD and IBS is essential for guiding clinicians in developing effective treatment strategies for patients affected by both conditions. This study aimed to evaluate the prevalence of GERD and IBS co-occurrence and highlighted the clinical significance of addressing this overlap to improve diagnosis, individualized treatment, and patient outcomes. A systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Scopus, and Web of Science were searched using the keywords “GERD” AND “IBS.” Twelve studies met the inclusion criteria and were analyzed. Statistical analyses were performed using Review Manager version 5.4. Pooled risk ratios (RRs) were calculated to assess the risk of co-occurrence between GERD and IBS. IBS was associated with a significantly increased risk of GERD, with a pooled RR of 3.55 (95% confidence interval [CI]: 2.40–5.25, p < 0.001; I² = 99%). Similarly, GERD was associated with an increased risk of IBS, with a pooled RR of 3.83 (95% CI: 2.81–5.22, p < 0.001; I² = 97%). The findings suggested a bidirectional relationship between GERD and IBS, potentially influenced by shared genetic or physiological mechanisms. Future research is needed to explore contributing factors and to develop strategies for managing the coexistence of these conditions to prevent complications.

Key words: Irritable bowel syndrome, Gastroesophageal reflux disease, Risk, Cooccurrence


 
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How to Cite this Article
Pubmed Style

Alharbi A, Altaleb K, Alrasheed M, Almashuf F, Aldayhani O, Alhassan A, Alsultan M, Alhamoudi A, Alosaimi M, Almutawa F, Alanazi A. Association between gastroesophageal reflux disease and irritable bowel syndrome: a systematic review and meta-analysis. IJMDC. 2024; 8(12): 3776-3783. doi:10.24911/IJMDC.51-1734190765

Web Style

Alharbi A, Altaleb K, Alrasheed M, Almashuf F, Aldayhani O, Alhassan A, Alsultan M, Alhamoudi A, Alosaimi M, Almutawa F, Alanazi A. Association between gastroesophageal reflux disease and irritable bowel syndrome: a systematic review and meta-analysis. https://www.ijmdc.com/?mno=232973 [Access: October 14, 2025]. doi:10.24911/IJMDC.51-1734190765

AMA (American Medical Association) Style

Alharbi A, Altaleb K, Alrasheed M, Almashuf F, Aldayhani O, Alhassan A, Alsultan M, Alhamoudi A, Alosaimi M, Almutawa F, Alanazi A. Association between gastroesophageal reflux disease and irritable bowel syndrome: a systematic review and meta-analysis. IJMDC. 2024; 8(12): 3776-3783. doi:10.24911/IJMDC.51-1734190765


Vancouver/ICMJE Style

Alharbi A, Altaleb K, Alrasheed M, Almashuf F, Aldayhani O, Alhassan A, Alsultan M, Alhamoudi A, Alosaimi M, Almutawa F, Alanazi A. Association between gastroesophageal reflux disease and irritable bowel syndrome: a systematic review and meta-analysis. IJMDC. (2024), [cited October 14, 2025]; 8(12): 3776-3783. doi:10.24911/IJMDC.51-1734190765


Harvard Style

Alharbi, A., Altaleb, . K., Alrasheed, . M., Almashuf, . F., Aldayhani, . O., Alhassan, . A., Alsultan, . M., Alhamoudi, . A., Alosaimi, . M., Almutawa, . F. & Alanazi, . A. (2024) Association between gastroesophageal reflux disease and irritable bowel syndrome: a systematic review and meta-analysis. IJMDC, 8 (12), 3776-3783. doi:10.24911/IJMDC.51-1734190765


Turabian Style

Alharbi, Abdullah, Khalid Altaleb, Mohammed Alrasheed, Faisal Almashuf, Omar Aldayhani, Abdulaziz Alhassan, Mohammad Alsultan, Abdullah Alhamoudi, Mohammed Alosaimi, Faisal Almutawa, and Asma Alanazi. 2024. Association between gastroesophageal reflux disease and irritable bowel syndrome: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 8 (12), 3776-3783. doi:10.24911/IJMDC.51-1734190765


Chicago Style

Alharbi, Abdullah, Khalid Altaleb, Mohammed Alrasheed, Faisal Almashuf, Omar Aldayhani, Abdulaziz Alhassan, Mohammad Alsultan, Abdullah Alhamoudi, Mohammed Alosaimi, Faisal Almutawa, and Asma Alanazi. "Association between gastroesophageal reflux disease and irritable bowel syndrome: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 8 (2024), 3776-3783. doi:10.24911/IJMDC.51-1734190765


MLA (The Modern Language Association) Style

Alharbi, Abdullah, Khalid Altaleb, Mohammed Alrasheed, Faisal Almashuf, Omar Aldayhani, Abdulaziz Alhassan, Mohammad Alsultan, Abdullah Alhamoudi, Mohammed Alosaimi, Faisal Almutawa, and Asma Alanazi. "Association between gastroesophageal reflux disease and irritable bowel syndrome: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 8.12 (2024), 3776-3783. Print. doi:10.24911/IJMDC.51-1734190765


APA (American Psychological Association) Style

Alharbi, A., Altaleb, . K., Alrasheed, . M., Almashuf, . F., Aldayhani, . O., Alhassan, . A., Alsultan, . M., Alhamoudi, . A., Alosaimi, . M., Almutawa, . F. & Alanazi, . A. (2024) Association between gastroesophageal reflux disease and irritable bowel syndrome: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 8 (12), 3776-3783. doi:10.24911/IJMDC.51-1734190765




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