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2025, Vol: 9, Issue: 9
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Review Article
Online Published: 03 Sep 2025
 


Efficacy and safety of statin therapy as adjunctive treatment for Helicobacter pylori eradication: a systematic review and meta-analysis

Maha Alaklabi, Aqeel Altuwaiyan, Abdullah Albariqi, Atheer Alharthi, Ranya Alsiddig, Abdulrahman Alahmadi, Rayan Alharbi, Amnah Alkedayci, Ahad Alaklabi, Abdulrazag Ibnshamsah, Abdullah M. Alshahrani.


Abstract
Helicobacter pylori infection affects over half of the global population, with growing antibiotic resistance compromising traditional eradication strategies. This systematic review and meta-analysis evaluated the efficacy and safety of statins as adjunctive therapy in H. pylori eradication regimens. A comprehensive search was conducted across multiple electronic databases through October 2023, including randomized controlled trials and observational studies comparing statin-supplemented versus standard eradication regimens. The primary outcome was the H. pylori eradication rate, and secondary outcomes included adverse events and treatment adherence. The risk of bias was assessed using the RoB 2 tool, and random-effects meta-analyses were performed. Six studies (n = 11,472) met the inclusion criteria. The primary analysis showed a non-significant trend favoring statin therapy (OR 1.25, 95% CI 0.53-2.93; I² = 88%). Sensitivity analysis excluding one discordant study yielded a significant benefit (OR 1.69, 95% CI 1.14-2.49; I² = 49%). Adverse events were more frequent with statin therapy (OR 2.34, 95% CI 1.89-2.89; I² = 0%). Treatment adherence consistently exceeded 85% across all groups. While statin therapy shows promise as an adjunctive treatment for H. pylori eradication, the increased risk of adverse events warrants careful patient selection. Future research should focus on optimizing statin protocols and identifying patient subgroups most likely to benefit from this approach.

Key words: Helicobacter Pylori, statin; antimicrobial drug resistance, HMG-CoA reductase inhibitors


 
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How to Cite this Article
Pubmed Style

Alaklabi M, Altuwaiyan A, Albariqi A, Alharthi A, Alsiddig R, Alahmadi A, Alharbi R, Alkedayci A, Alaklabi A, Ibnshamsah A, Alshahrani AM. Efficacy and safety of statin therapy as adjunctive treatment for Helicobacter pylori eradication: a systematic review and meta-analysis. IJMDC. 2025; 9(7): 1613-1621. doi:10.24911/IJMDC.51-1743848544

Web Style

Alaklabi M, Altuwaiyan A, Albariqi A, Alharthi A, Alsiddig R, Alahmadi A, Alharbi R, Alkedayci A, Alaklabi A, Ibnshamsah A, Alshahrani AM. Efficacy and safety of statin therapy as adjunctive treatment for Helicobacter pylori eradication: a systematic review and meta-analysis. https://www.ijmdc.com/?mno=250852 [Access: October 14, 2025]. doi:10.24911/IJMDC.51-1743848544

AMA (American Medical Association) Style

Alaklabi M, Altuwaiyan A, Albariqi A, Alharthi A, Alsiddig R, Alahmadi A, Alharbi R, Alkedayci A, Alaklabi A, Ibnshamsah A, Alshahrani AM. Efficacy and safety of statin therapy as adjunctive treatment for Helicobacter pylori eradication: a systematic review and meta-analysis. IJMDC. 2025; 9(7): 1613-1621. doi:10.24911/IJMDC.51-1743848544


Vancouver/ICMJE Style

Alaklabi M, Altuwaiyan A, Albariqi A, Alharthi A, Alsiddig R, Alahmadi A, Alharbi R, Alkedayci A, Alaklabi A, Ibnshamsah A, Alshahrani AM. Efficacy and safety of statin therapy as adjunctive treatment for Helicobacter pylori eradication: a systematic review and meta-analysis. IJMDC. (2025), [cited October 14, 2025]; 9(7): 1613-1621. doi:10.24911/IJMDC.51-1743848544


Harvard Style

Alaklabi, M., Altuwaiyan, . A., Albariqi, . A., Alharthi, . A., Alsiddig, . R., Alahmadi, . A., Alharbi, . R., Alkedayci, . A., Alaklabi, . A., Ibnshamsah, . A. & Alshahrani, . A. M. (2025) Efficacy and safety of statin therapy as adjunctive treatment for Helicobacter pylori eradication: a systematic review and meta-analysis. IJMDC, 9 (7), 1613-1621. doi:10.24911/IJMDC.51-1743848544


Turabian Style

Alaklabi, Maha, Aqeel Altuwaiyan, Abdullah Albariqi, Atheer Alharthi, Ranya Alsiddig, Abdulrahman Alahmadi, Rayan Alharbi, Amnah Alkedayci, Ahad Alaklabi, Abdulrazag Ibnshamsah, and Abdullah M. Alshahrani. 2025. Efficacy and safety of statin therapy as adjunctive treatment for Helicobacter pylori eradication: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 9 (7), 1613-1621. doi:10.24911/IJMDC.51-1743848544


Chicago Style

Alaklabi, Maha, Aqeel Altuwaiyan, Abdullah Albariqi, Atheer Alharthi, Ranya Alsiddig, Abdulrahman Alahmadi, Rayan Alharbi, Amnah Alkedayci, Ahad Alaklabi, Abdulrazag Ibnshamsah, and Abdullah M. Alshahrani. "Efficacy and safety of statin therapy as adjunctive treatment for Helicobacter pylori eradication: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 9 (2025), 1613-1621. doi:10.24911/IJMDC.51-1743848544


MLA (The Modern Language Association) Style

Alaklabi, Maha, Aqeel Altuwaiyan, Abdullah Albariqi, Atheer Alharthi, Ranya Alsiddig, Abdulrahman Alahmadi, Rayan Alharbi, Amnah Alkedayci, Ahad Alaklabi, Abdulrazag Ibnshamsah, and Abdullah M. Alshahrani. "Efficacy and safety of statin therapy as adjunctive treatment for Helicobacter pylori eradication: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 9.7 (2025), 1613-1621. Print. doi:10.24911/IJMDC.51-1743848544


APA (American Psychological Association) Style

Alaklabi, M., Altuwaiyan, . A., Albariqi, . A., Alharthi, . A., Alsiddig, . R., Alahmadi, . A., Alharbi, . R., Alkedayci, . A., Alaklabi, . A., Ibnshamsah, . A. & Alshahrani, . A. M. (2025) Efficacy and safety of statin therapy as adjunctive treatment for Helicobacter pylori eradication: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 9 (7), 1613-1621. doi:10.24911/IJMDC.51-1743848544




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