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2026, Vol: 10, Issue: 3
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Online Published: 28 Dec 2025
 


Invasive Cerebral aspergillosis in an immunocompetent patient following endoscopic sinus surgery: a diagnostic challenge: case report

Thamir Saad Alsaeed, Yahya Shabi, Sarah Habbash, Saeed Ms Alhamhhum, Mohammed Ali M. Alasiri, Alaa Hatim Ameer Mohamed.


Abstract
Background. Invasive cerebral aspergillosis is an uncommon and potentially fatal condition usually occurs in immunocompromised patients but may develop in immunocompetent individuals, particularly after undergoing sinus surgery.
Case presentation: A 45-year-old man with no past medical history other than sinus surgery presented to the E.R. with fever, generalized seizures, and altered mental status. After the initial workup, he was diagnosed with malaria, which was incorrect and deteriorated with treatment. Brain imaging revealed a frontal mass with sinus involvement and midline shift. So, he had a craniectomy with the excision of necrotic brain tissue. Histologic examination showed necrotizing Aspergillus angiitis from Aspergillus fumigatus. He had a good response to voriconazole therapy.
Conclusion: This case emphasizes the need to rule out fungal infections of the central nervous system in patients with a history of uncomplicated sinus surgery and unexplainable neurologic signs and symptoms.

Key words: Aspergillus, cerebral aspergillosis, fungal brain infection, sinus surgery, voriconazole.


 
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How to Cite this Article
Pubmed Style

Alsaeed TS, Shabi Y, Habbash S, Alhamhhum SM, Alasiri MAM, Mohamed AHA. Invasive Cerebral aspergillosis in an immunocompetent patient following endoscopic sinus surgery: a diagnostic challenge: case report. IJMDC. 2025; 9(12): 3432-3435. doi:10.24911/IJMDC.51-1744922494

Web Style

Alsaeed TS, Shabi Y, Habbash S, Alhamhhum SM, Alasiri MAM, Mohamed AHA. Invasive Cerebral aspergillosis in an immunocompetent patient following endoscopic sinus surgery: a diagnostic challenge: case report. https://www.ijmdc.com/?mno=253222 [Access: January 17, 2026]. doi:10.24911/IJMDC.51-1744922494

AMA (American Medical Association) Style

Alsaeed TS, Shabi Y, Habbash S, Alhamhhum SM, Alasiri MAM, Mohamed AHA. Invasive Cerebral aspergillosis in an immunocompetent patient following endoscopic sinus surgery: a diagnostic challenge: case report. IJMDC. 2025; 9(12): 3432-3435. doi:10.24911/IJMDC.51-1744922494


Vancouver/ICMJE Style

Alsaeed TS, Shabi Y, Habbash S, Alhamhhum SM, Alasiri MAM, Mohamed AHA. Invasive Cerebral aspergillosis in an immunocompetent patient following endoscopic sinus surgery: a diagnostic challenge: case report. IJMDC. (2025), [cited January 17, 2026]; 9(12): 3432-3435. doi:10.24911/IJMDC.51-1744922494


Harvard Style

Alsaeed, T. S., Shabi, . Y., Habbash, . S., Alhamhhum, . S. M., Alasiri, . M. A. M. & Mohamed, . A. H. A. (2025) Invasive Cerebral aspergillosis in an immunocompetent patient following endoscopic sinus surgery: a diagnostic challenge: case report. IJMDC, 9 (12), 3432-3435. doi:10.24911/IJMDC.51-1744922494


Turabian Style

Alsaeed, Thamir Saad, Yahya Shabi, Sarah Habbash, Saeed Ms Alhamhhum, Mohammed Ali M. Alasiri, and Alaa Hatim Ameer Mohamed. 2025. Invasive Cerebral aspergillosis in an immunocompetent patient following endoscopic sinus surgery: a diagnostic challenge: case report. International Journal of Medicine in Developing Countries, 9 (12), 3432-3435. doi:10.24911/IJMDC.51-1744922494


Chicago Style

Alsaeed, Thamir Saad, Yahya Shabi, Sarah Habbash, Saeed Ms Alhamhhum, Mohammed Ali M. Alasiri, and Alaa Hatim Ameer Mohamed. "Invasive Cerebral aspergillosis in an immunocompetent patient following endoscopic sinus surgery: a diagnostic challenge: case report." International Journal of Medicine in Developing Countries 9 (2025), 3432-3435. doi:10.24911/IJMDC.51-1744922494


MLA (The Modern Language Association) Style

Alsaeed, Thamir Saad, Yahya Shabi, Sarah Habbash, Saeed Ms Alhamhhum, Mohammed Ali M. Alasiri, and Alaa Hatim Ameer Mohamed. "Invasive Cerebral aspergillosis in an immunocompetent patient following endoscopic sinus surgery: a diagnostic challenge: case report." International Journal of Medicine in Developing Countries 9.12 (2025), 3432-3435. Print. doi:10.24911/IJMDC.51-1744922494


APA (American Psychological Association) Style

Alsaeed, T. S., Shabi, . Y., Habbash, . S., Alhamhhum, . S. M., Alasiri, . M. A. M. & Mohamed, . A. H. A. (2025) Invasive Cerebral aspergillosis in an immunocompetent patient following endoscopic sinus surgery: a diagnostic challenge: case report. International Journal of Medicine in Developing Countries, 9 (12), 3432-3435. doi:10.24911/IJMDC.51-1744922494




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