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Review Article
Online Published: 13 Dec 2025
 


Assessment of cardiovascular complications in patients with atopic dermatitis using systematic abrocitinib: a systematic review and meta-analysis

Hosam Hadi Awaji, Imtinan Mofarrej Alsobhi, Mayar Mubarak Alkalbi, Sadiq Jaafar Alasfoor, Feras Sabri Nasser Makeen, Ahmed Ibrahim Binammar, Alreem Abdulaziz Alabbas, Husam Mohammad Alghamdi, Khadijah Abdulrahman Alrajhi, Sultanah Salem Alrashedi.


Abstract
Atopic dermatitis (AD) is becoming acknowledged as a systemic inflammatory disorder potentially linked to elevated cardiovascular risk. Abrocitinib, a selective inhibitor of Janus kinase 1 (JAK1) authorized for moderate-to-severe AD, demonstrates significant therapeutic efficacy. Concerns over the cardiovascular safety of JAK inhibitors have necessitated the assessment of major adverse cardiovascular events (MACE) and venous thromboembolism (VTE) in patients treated with abrocitinib. A comprehensive review and meta-analysis were performed of randomized controlled trials (RCTs) assessing abrocitinib versus placebo in individuals with moderate-to-severe AD. A thorough search of PubMed, MEDLINE, Scopus, Ovid, and CENTRAL databases
was conducted. The principal result was the occurrence of MACE; the secondary outcome was VTE. Six RCTs with 2,338 patients (1,703 receiving abrocitinib; 635 receiving placebo) were included. MACE was observed in one patient from each group, resulting in a pooled risk difference (RD) of 0.00 [95% confidence intervals (CI): -0.00 to 0.00; p-value = 0.96]. Two VTE occurrences transpired in the abrocitinib cohort, whereas none
were observed in the placebo cohort, yielding a pooled RD of 0.00 (95% CI: -0.00 to 0.01; p-value = 0.64). No heterogeneity was detected among the trials (I² = 0%). This meta-analysis revealed no elevated risk of MACE or VTE linked to abrocitinib in patients with moderate-to-severe AD during short- to mid-term follow-up. Although the findings are encouraging, more pharmacovigilance and longitudinal investigations are necessary to validate cardiovascular safety in larger groups.

Key words: Atopic dermatitis, abrocitinib, JAK1 inhibitor, cardiovascular safety, major adverse cardiovascular events, venous thromboembolism, meta-analysis.


 
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How to Cite this Article
Pubmed Style

Awaji HH, Alsobhi IM, Alkalbi MM, Alasfoor SJ, Makeen FSN, Binammar AI, Alabbas AA, Alghamdi HM, Alrajhi KA, Alrashedi SS. Assessment of cardiovascular complications in patients with atopic dermatitis using systematic abrocitinib: a systematic review and meta-analysis. IJMDC. 2025; 9(11): 2983-2991. doi:10.24911/IJMDC.51-1763753114

Web Style

Awaji HH, Alsobhi IM, Alkalbi MM, Alasfoor SJ, Makeen FSN, Binammar AI, Alabbas AA, Alghamdi HM, Alrajhi KA, Alrashedi SS. Assessment of cardiovascular complications in patients with atopic dermatitis using systematic abrocitinib: a systematic review and meta-analysis. https://www.ijmdc.com/?mno=298505 [Access: June 23, 2026]. doi:10.24911/IJMDC.51-1763753114

AMA (American Medical Association) Style

Awaji HH, Alsobhi IM, Alkalbi MM, Alasfoor SJ, Makeen FSN, Binammar AI, Alabbas AA, Alghamdi HM, Alrajhi KA, Alrashedi SS. Assessment of cardiovascular complications in patients with atopic dermatitis using systematic abrocitinib: a systematic review and meta-analysis. IJMDC. 2025; 9(11): 2983-2991. doi:10.24911/IJMDC.51-1763753114


Vancouver/ICMJE Style

Awaji HH, Alsobhi IM, Alkalbi MM, Alasfoor SJ, Makeen FSN, Binammar AI, Alabbas AA, Alghamdi HM, Alrajhi KA, Alrashedi SS. Assessment of cardiovascular complications in patients with atopic dermatitis using systematic abrocitinib: a systematic review and meta-analysis. IJMDC. (2025), [cited June 23, 2026]; 9(11): 2983-2991. doi:10.24911/IJMDC.51-1763753114


Harvard Style

Awaji, H. H., Alsobhi, . I. M., Alkalbi, . M. M., Alasfoor, . S. J., Makeen, . F. S. N., Binammar, . A. I., Alabbas, . A. A., Alghamdi, . H. M., Alrajhi, . K. A. & Alrashedi, . S. S. (2025) Assessment of cardiovascular complications in patients with atopic dermatitis using systematic abrocitinib: a systematic review and meta-analysis. IJMDC, 9 (11), 2983-2991. doi:10.24911/IJMDC.51-1763753114


Turabian Style

Awaji, Hosam Hadi, Imtinan Mofarrej Alsobhi, Mayar Mubarak Alkalbi, Sadiq Jaafar Alasfoor, Feras Sabri Nasser Makeen, Ahmed Ibrahim Binammar, Alreem Abdulaziz Alabbas, Husam Mohammad Alghamdi, Khadijah Abdulrahman Alrajhi, and Sultanah Salem Alrashedi. 2025. Assessment of cardiovascular complications in patients with atopic dermatitis using systematic abrocitinib: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 9 (11), 2983-2991. doi:10.24911/IJMDC.51-1763753114


Chicago Style

Awaji, Hosam Hadi, Imtinan Mofarrej Alsobhi, Mayar Mubarak Alkalbi, Sadiq Jaafar Alasfoor, Feras Sabri Nasser Makeen, Ahmed Ibrahim Binammar, Alreem Abdulaziz Alabbas, Husam Mohammad Alghamdi, Khadijah Abdulrahman Alrajhi, and Sultanah Salem Alrashedi. "Assessment of cardiovascular complications in patients with atopic dermatitis using systematic abrocitinib: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 9 (2025), 2983-2991. doi:10.24911/IJMDC.51-1763753114


MLA (The Modern Language Association) Style

Awaji, Hosam Hadi, Imtinan Mofarrej Alsobhi, Mayar Mubarak Alkalbi, Sadiq Jaafar Alasfoor, Feras Sabri Nasser Makeen, Ahmed Ibrahim Binammar, Alreem Abdulaziz Alabbas, Husam Mohammad Alghamdi, Khadijah Abdulrahman Alrajhi, and Sultanah Salem Alrashedi. "Assessment of cardiovascular complications in patients with atopic dermatitis using systematic abrocitinib: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 9.11 (2025), 2983-2991. Print. doi:10.24911/IJMDC.51-1763753114


APA (American Psychological Association) Style

Awaji, H. H., Alsobhi, . I. M., Alkalbi, . M. M., Alasfoor, . S. J., Makeen, . F. S. N., Binammar, . A. I., Alabbas, . A. A., Alghamdi, . H. M., Alrajhi, . K. A. & Alrashedi, . S. S. (2025) Assessment of cardiovascular complications in patients with atopic dermatitis using systematic abrocitinib: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 9 (11), 2983-2991. doi:10.24911/IJMDC.51-1763753114




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