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2026, Vol: 10, Issue: 1
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Review Article
Online Published: 21 Jan 2026
 


Baricitinib efficacy and safety for bullous pemphigoid: systematic review and meta-analysis

Shaden Ahmed Abdullah Alhazmi, Mariyah Ahmed A. Alyahya, Ohud Ahmed Jaber Alnaji, Nada Ali Ahmed Alshahrani, Ola Gamil Saleh Abdo Mohammed, Rand Nasser Abdullah Alzamil, Zahra Mohammad Hadi Asiri, Sarah Dhafer Saad Alqarni, Jamilah Masoud Mohammed Ghazwani, Asim M. Shadid, Mohammed A. Almashali, Arwa O. Almodayfer.


Abstract
Bullous pemphigoid (BP) is considered a chronic autoimmune blistering disorder that affects the elderly and is often associated with long-term immunosuppressive management. Traditional treatment of BP included the use of corticosteroids and immunosuppressants, which can be associated with significant side effects and have limited efficacy in refractory cases. Janus kinase (JAK) inhibitors, including baricitinib, have emerged as potential therapeutic options because of their efficacy in modulating immune response. The current review aimed to systematically evaluate the clinical outcomes of using baricitinib in the management of BP. The data was extracted from a total of five studies, including case reports and case series, regarding patient demographics, comorbidities, clinical presentation, baseline severity of disease, regimen of baricitinib treatment, and outcomes of the management, including clinical improvement, rate of remission, and incidence of adverse events. This review included a total of 13 patients diagnosed with BP with administration of baricitinib at a dose of 4 mg/day. The clinical improvement was observed within 1-4 weeks of treatment, and complete remission within 14.75 weeks (95% CI: 9.69-19.82). The patients reported a significant reduction in Bullous Pemphigoid Disease Area Index (BPDAI) and Visual Analogue Scale (VAS) scores, with many patients reporting tapering or discontinuation of corticosteroids and other immunosuppressants. The use of baricitinib showed good effectiveness and well-tolerated therapeutic outcomes, especially among those with refractory disorder or intolerance to traditional treatment. It was associated with a rapid onset of action, steroid-sparing ability, and a favorable safety profile, indicating its promising role as an emerging treatment strategy.

Key words: Baricitinib, Janus kinase inhibitors, bullous pemphigoid, autoimmune blistering diseases, efficacy, safety, systematic review, meta-analysis.


 
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How to Cite this Article
Pubmed Style

Alhazmi SAA, Alyahya MAA, Alnaji OAJ, Alshahrani NAA, Mohammed OGSA, Alzamil RNA, Asiri ZMH, Alqarni SDS, Ghazwani JMM, Shadid AM, Almashali MA, Almodayfer AO. Baricitinib efficacy and safety for bullous pemphigoid: systematic review and meta-analysis. IJMDC. 2026; 10(1): 417-423. doi:10.24911/IJMDC.51-1765350017

Web Style

Alhazmi SAA, Alyahya MAA, Alnaji OAJ, Alshahrani NAA, Mohammed OGSA, Alzamil RNA, Asiri ZMH, Alqarni SDS, Ghazwani JMM, Shadid AM, Almashali MA, Almodayfer AO. Baricitinib efficacy and safety for bullous pemphigoid: systematic review and meta-analysis. https://www.ijmdc.com/?mno=302630 [Access: January 25, 2026]. doi:10.24911/IJMDC.51-1765350017

AMA (American Medical Association) Style

Alhazmi SAA, Alyahya MAA, Alnaji OAJ, Alshahrani NAA, Mohammed OGSA, Alzamil RNA, Asiri ZMH, Alqarni SDS, Ghazwani JMM, Shadid AM, Almashali MA, Almodayfer AO. Baricitinib efficacy and safety for bullous pemphigoid: systematic review and meta-analysis. IJMDC. 2026; 10(1): 417-423. doi:10.24911/IJMDC.51-1765350017


Vancouver/ICMJE Style

Alhazmi SAA, Alyahya MAA, Alnaji OAJ, Alshahrani NAA, Mohammed OGSA, Alzamil RNA, Asiri ZMH, Alqarni SDS, Ghazwani JMM, Shadid AM, Almashali MA, Almodayfer AO. Baricitinib efficacy and safety for bullous pemphigoid: systematic review and meta-analysis. IJMDC. (2026), [cited January 25, 2026]; 10(1): 417-423. doi:10.24911/IJMDC.51-1765350017


Harvard Style

Alhazmi, S. A. A., Alyahya, . M. A. A., Alnaji, . O. A. J., Alshahrani, . N. A. A., Mohammed, . O. G. S. A., Alzamil, . R. N. A., Asiri, . Z. M. H., Alqarni, . S. D. S., Ghazwani, . J. M. M., Shadid, . A. M., Almashali, . M. A. & Almodayfer, . A. O. (2026) Baricitinib efficacy and safety for bullous pemphigoid: systematic review and meta-analysis. IJMDC, 10 (1), 417-423. doi:10.24911/IJMDC.51-1765350017


Turabian Style

Alhazmi, Shaden Ahmed Abdullah, Mariyah Ahmed A. Alyahya, Ohud Ahmed Jaber Alnaji, Nada Ali Ahmed Alshahrani, Ola Gamil Saleh Abdo Mohammed, Rand Nasser Abdullah Alzamil, Zahra Mohammad Hadi Asiri, Sarah Dhafer Saad Alqarni, Jamilah Masoud Mohammed Ghazwani, Asim M. Shadid, Mohammed A. Almashali, and Arwa O. Almodayfer. 2026. Baricitinib efficacy and safety for bullous pemphigoid: systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 10 (1), 417-423. doi:10.24911/IJMDC.51-1765350017


Chicago Style

Alhazmi, Shaden Ahmed Abdullah, Mariyah Ahmed A. Alyahya, Ohud Ahmed Jaber Alnaji, Nada Ali Ahmed Alshahrani, Ola Gamil Saleh Abdo Mohammed, Rand Nasser Abdullah Alzamil, Zahra Mohammad Hadi Asiri, Sarah Dhafer Saad Alqarni, Jamilah Masoud Mohammed Ghazwani, Asim M. Shadid, Mohammed A. Almashali, and Arwa O. Almodayfer. "Baricitinib efficacy and safety for bullous pemphigoid: systematic review and meta-analysis." International Journal of Medicine in Developing Countries 10 (2026), 417-423. doi:10.24911/IJMDC.51-1765350017


MLA (The Modern Language Association) Style

Alhazmi, Shaden Ahmed Abdullah, Mariyah Ahmed A. Alyahya, Ohud Ahmed Jaber Alnaji, Nada Ali Ahmed Alshahrani, Ola Gamil Saleh Abdo Mohammed, Rand Nasser Abdullah Alzamil, Zahra Mohammad Hadi Asiri, Sarah Dhafer Saad Alqarni, Jamilah Masoud Mohammed Ghazwani, Asim M. Shadid, Mohammed A. Almashali, and Arwa O. Almodayfer. "Baricitinib efficacy and safety for bullous pemphigoid: systematic review and meta-analysis." International Journal of Medicine in Developing Countries 10.1 (2026), 417-423. Print. doi:10.24911/IJMDC.51-1765350017


APA (American Psychological Association) Style

Alhazmi, S. A. A., Alyahya, . M. A. A., Alnaji, . O. A. J., Alshahrani, . N. A. A., Mohammed, . O. G. S. A., Alzamil, . R. N. A., Asiri, . Z. M. H., Alqarni, . S. D. S., Ghazwani, . J. M. M., Shadid, . A. M., Almashali, . M. A. & Almodayfer, . A. O. (2026) Baricitinib efficacy and safety for bullous pemphigoid: systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 10 (1), 417-423. doi:10.24911/IJMDC.51-1765350017




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