The efficacy of platelet-rich plasma for lumbar spinal pain: a systematic review and meta-analysis of randomized controlled trials

Fatima Bassam AlAlqam; Zainab F. Alshaikh; Batool Meshal H. Alorayyidh; Ziyad Sulaiman Alnasyan; Abdulsalam Mohammed Aleid; Yezeid Almohsen; Saleh Khalid Alsheraiwi

doi:10.24911/IJMDC.51-1766170083

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Review Article
Online Published: 18 Jan 2026

IJMDC. 2026; 10(1): 507-513

doi: 10.24911/IJMDC.51-1766170083

The efficacy of platelet-rich plasma for lumbar spinal pain: a systematic review and meta-analysis of randomized controlled trials

Abdulsalam Mohammed Aleid, Yezeid Almohsen, Hussam Alqifari, Roba Alnazawi, Fatimah Alghannam, Qutaybah Alhawday, Mohammed Alobaysi, Sami Fadhel Almalki, Fatima Bassam Alalqam, Zainab F. Alshaikh, Batool Meshal H. Alorayyidh, Ziyad Sulaiman Alnasyan, Saleh Khalid Alsheraiwi.

Abstract
Platelet-rich plasma therapy is another biological method of treatment of lumbar spinal pain, which has received attention; however, its actual clinical value remains unknown. This systematic review and meta-analysis investigated the efficacy of platelet-rich plasma therapy compared with other therapies for the management of lumbar spinal pain. The searches were conducted in Medline (PubMed), Cochrane CENTRAL, Scopus, and Google Scholar to identify the randomized controlled trials. The Review Manager 5.4 was used to pool the available data, and the Cochrane Risk of Bias tool was used to assess the quality of the studies. The analyzed sample comprised 6 trials with 236 patients. Overall, as compared to alternative therapies, platelet-rich plasma therapy did not significantly alter pain intensity or impairment levels as measured by the Visual Analogue Scale and Oswestry Impairment Index. Even while the SF-36 scale showed an increase in physical discomfort, the changes in physical functioning were negligible and not statistically significant. To recap, no clear benefit of platelet-rich plasma therapy was found compared to existing treatments for lumbar spinal pain. To better understand its role in clinical practice, larger, well-designed randomized controlled trials are needed.

Key words: Platelet rich plasma, lumbar pain, disc herniation, lumbar fusion, meta-analysis.

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Pubmed Style

Aleid AM, Almohsen Y, Alqifari H, Alnazawi R, Alghannam F, Alhawday Q, Alobaysi M, Almalki SF, Alalqam FB, Alshaikh ZF, Alorayyidh BMH, Alnasyan ZS, Alsheraiwi SK. The efficacy of platelet-rich plasma for lumbar spinal pain: a systematic review and meta-analysis of randomized controlled trials. IJMDC. 2026; 10(1): 507-513. doi:10.24911/IJMDC.51-1766170083

Web Style

Aleid AM, Almohsen Y, Alqifari H, Alnazawi R, Alghannam F, Alhawday Q, Alobaysi M, Almalki SF, Alalqam FB, Alshaikh ZF, Alorayyidh BMH, Alnasyan ZS, Alsheraiwi SK. The efficacy of platelet-rich plasma for lumbar spinal pain: a systematic review and meta-analysis of randomized controlled trials. https://www.ijmdc.com/?mno=303813 [Access: January 25, 2026]. doi:10.24911/IJMDC.51-1766170083

AMA (American Medical Association) Style

Aleid AM, Almohsen Y, Alqifari H, Alnazawi R, Alghannam F, Alhawday Q, Alobaysi M, Almalki SF, Alalqam FB, Alshaikh ZF, Alorayyidh BMH, Alnasyan ZS, Alsheraiwi SK. The efficacy of platelet-rich plasma for lumbar spinal pain: a systematic review and meta-analysis of randomized controlled trials. IJMDC. 2026; 10(1): 507-513. doi:10.24911/IJMDC.51-1766170083

Vancouver/ICMJE Style

Aleid AM, Almohsen Y, Alqifari H, Alnazawi R, Alghannam F, Alhawday Q, Alobaysi M, Almalki SF, Alalqam FB, Alshaikh ZF, Alorayyidh BMH, Alnasyan ZS, Alsheraiwi SK. The efficacy of platelet-rich plasma for lumbar spinal pain: a systematic review and meta-analysis of randomized controlled trials. IJMDC. (2026), [cited January 25, 2026]; 10(1): 507-513. doi:10.24911/IJMDC.51-1766170083

Harvard Style

Aleid, A. M., Almohsen, . Y., Alqifari, . H., Alnazawi, . R., Alghannam, . F., Alhawday, . Q., Alobaysi, . M., Almalki, . S. F., Alalqam, . F. B., Alshaikh, . Z. F., Alorayyidh, . B. M. H., Alnasyan, . Z. S. & Alsheraiwi, . S. K. (2026) The efficacy of platelet-rich plasma for lumbar spinal pain: a systematic review and meta-analysis of randomized controlled trials. IJMDC, 10 (1), 507-513. doi:10.24911/IJMDC.51-1766170083

Turabian Style

Aleid, Abdulsalam Mohammed, Yezeid Almohsen, Hussam Alqifari, Roba Alnazawi, Fatimah Alghannam, Qutaybah Alhawday, Mohammed Alobaysi, Sami Fadhel Almalki, Fatima Bassam Alalqam, Zainab F. Alshaikh, Batool Meshal H. Alorayyidh, Ziyad Sulaiman Alnasyan, and Saleh Khalid Alsheraiwi. 2026. The efficacy of platelet-rich plasma for lumbar spinal pain: a systematic review and meta-analysis of randomized controlled trials. International Journal of Medicine in Developing Countries, 10 (1), 507-513. doi:10.24911/IJMDC.51-1766170083

Chicago Style

Aleid, Abdulsalam Mohammed, Yezeid Almohsen, Hussam Alqifari, Roba Alnazawi, Fatimah Alghannam, Qutaybah Alhawday, Mohammed Alobaysi, Sami Fadhel Almalki, Fatima Bassam Alalqam, Zainab F. Alshaikh, Batool Meshal H. Alorayyidh, Ziyad Sulaiman Alnasyan, and Saleh Khalid Alsheraiwi. "The efficacy of platelet-rich plasma for lumbar spinal pain: a systematic review and meta-analysis of randomized controlled trials." International Journal of Medicine in Developing Countries 10 (2026), 507-513. doi:10.24911/IJMDC.51-1766170083

MLA (The Modern Language Association) Style

Aleid, Abdulsalam Mohammed, Yezeid Almohsen, Hussam Alqifari, Roba Alnazawi, Fatimah Alghannam, Qutaybah Alhawday, Mohammed Alobaysi, Sami Fadhel Almalki, Fatima Bassam Alalqam, Zainab F. Alshaikh, Batool Meshal H. Alorayyidh, Ziyad Sulaiman Alnasyan, and Saleh Khalid Alsheraiwi. "The efficacy of platelet-rich plasma for lumbar spinal pain: a systematic review and meta-analysis of randomized controlled trials." International Journal of Medicine in Developing Countries 10.1 (2026), 507-513. Print. doi:10.24911/IJMDC.51-1766170083

APA (American Psychological Association) Style

Aleid, A. M., Almohsen, . Y., Alqifari, . H., Alnazawi, . R., Alghannam, . F., Alhawday, . Q., Alobaysi, . M., Almalki, . S. F., Alalqam, . F. B., Alshaikh, . Z. F., Alorayyidh, . B. M. H., Alnasyan, . Z. S. & Alsheraiwi, . S. K. (2026) The efficacy of platelet-rich plasma for lumbar spinal pain: a systematic review and meta-analysis of randomized controlled trials. International Journal of Medicine in Developing Countries, 10 (1), 507-513. doi:10.24911/IJMDC.51-1766170083

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