E-ISSN 1658-7820
 
2026, Vol: 10, Issue: 1
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Review Article
Online Published: 21 Jan 2026
 


Prevention of sickle cell crisis: Role of disease-modifying therapies and lifestyle interventions

Khalid Alhumam, Rasmah Alharajin.


Abstract
Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by recurrent vaso-occlusive crises (VOCs), chronic hemolytic anemia, and progressive organ damage. Acute sickle cell crises are the leading cause of morbidity, mortality, and healthcare utilization among affected individuals. Preventing these crises remains a cornerstone of SCD management. This review explores the role of disease-modifying pharmacologic therapies and lifestyle interventions in reducing the frequency and severity of sickle cell crises. Evidence supporting the use of hydroxyurea, L-glutamine, voxelotor, crizanlizumab, and curative approaches such as hematopoietic stem cell transplantation and emerging gene-based therapies is discussed. Additionally, the impact of lifestyle measures including hydration, infection prevention, nutrition, physical activity, and psychosocial support is reviewed. A combined approach integrating pharmacologic and non-pharmacologic strategies is essential for optimal long-term outcomes in patients with SCD.

Key words: Sickle Cell Crisis، Hydroxyurea، Crizanlizumab، Voxelotor.


 
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How to Cite this Article
Pubmed Style

Alhumam K, Alharajin R. Prevention of sickle cell crisis: Role of disease-modifying therapies and lifestyle interventions. IJMDC. 2026; 10(1): 545-549. doi:10.24911/IJMDC.51-1766938191

Web Style

Alhumam K, Alharajin R. Prevention of sickle cell crisis: Role of disease-modifying therapies and lifestyle interventions. https://www.ijmdc.com/?mno=304789 [Access: January 25, 2026]. doi:10.24911/IJMDC.51-1766938191

AMA (American Medical Association) Style

Alhumam K, Alharajin R. Prevention of sickle cell crisis: Role of disease-modifying therapies and lifestyle interventions. IJMDC. 2026; 10(1): 545-549. doi:10.24911/IJMDC.51-1766938191


Vancouver/ICMJE Style

Alhumam K, Alharajin R. Prevention of sickle cell crisis: Role of disease-modifying therapies and lifestyle interventions. IJMDC. (2026), [cited January 25, 2026]; 10(1): 545-549. doi:10.24911/IJMDC.51-1766938191


Harvard Style

Alhumam, K. & Alharajin, . R. (2026) Prevention of sickle cell crisis: Role of disease-modifying therapies and lifestyle interventions. IJMDC, 10 (1), 545-549. doi:10.24911/IJMDC.51-1766938191


Turabian Style

Alhumam, Khalid, and Rasmah Alharajin. 2026. Prevention of sickle cell crisis: Role of disease-modifying therapies and lifestyle interventions. International Journal of Medicine in Developing Countries, 10 (1), 545-549. doi:10.24911/IJMDC.51-1766938191


Chicago Style

Alhumam, Khalid, and Rasmah Alharajin. "Prevention of sickle cell crisis: Role of disease-modifying therapies and lifestyle interventions." International Journal of Medicine in Developing Countries 10 (2026), 545-549. doi:10.24911/IJMDC.51-1766938191


MLA (The Modern Language Association) Style

Alhumam, Khalid, and Rasmah Alharajin. "Prevention of sickle cell crisis: Role of disease-modifying therapies and lifestyle interventions." International Journal of Medicine in Developing Countries 10.1 (2026), 545-549. Print. doi:10.24911/IJMDC.51-1766938191


APA (American Psychological Association) Style

Alhumam, K. & Alharajin, . R. (2026) Prevention of sickle cell crisis: Role of disease-modifying therapies and lifestyle interventions. International Journal of Medicine in Developing Countries, 10 (1), 545-549. doi:10.24911/IJMDC.51-1766938191




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