Early-Onset Hidradenitis Suppurativa with DOCK8-Deficiency Hyper-IgE Syndrome: A Pediatric Case Report

Saleh Alkamees; Layan F Alsanad; Rawan Alanazi; Farah Albakr; Sharifah Almasoud; Sadeem Alhelal

doi:10.24911/IJMDC.51-1775089334

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Online Published: 22 May 2026

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doi: 10.24911/IJMDC.51-1775089334

Early-Onset Hidradenitis Suppurativa with DOCK8-Deficiency Hyper-IgE Syndrome: A Pediatric Case Report

Saleh Alkamees, Layan F Alsanad, Rawan Alanazi, Farah Albakr, Sharifah Almasoud, Sadeem Alhelal.

Abstract
Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the pilosebaceous unit that typically occurs after puberty and is rarely reported in young children. Early-onset cases may indicate an underlying genetic or immunologic disorder. We report an 8-year-old female with severe atopic dermatitis, bronchial asthma, and multiple food allergies who presented with recurrent painful abscesses involving the axilla and buttocks. Examination revealed inflammatory nodules and sinus tract formation in the right axilla consistent with HS. Laboratory testing showed markedly elevated serum IgE levels (12,609 IU/mL) and reduced IgM. Whole-exome sequencing identified a homozygous pathogenic deletion in exons 8–9 of the DOCK8 gene, confirming DOCK8-deficiency Hyper-IgE syndrome. The patient was treated with oral doxycycline, topical clindamycin, topical corticosteroids, antiseptic washes, and supportive skin care with partial improvement. Her course was complicated by severe ceftriaxone-induced anaphylaxis during hospitalization for influenza-associated pneumonia. This case highlights the rare association between early-onset HS and DOCK8 deficiency and underscores the importance of considering inborn errors of immunity in pediatric patients with atypical or severe HS to guide appropriate multidisciplinary management.

Key words: Hidradenitis suppurativa, DOCK8 deficiency, Hyper-IgE syndrome, Dermatology, Pediatrics

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Pubmed Style

Alkamees S, Alsanad LF, Alanazi R, Albakr F, Almasoud S, Alhelal S. Early-Onset Hidradenitis Suppurativa with DOCK8-Deficiency Hyper-IgE Syndrome: A Pediatric Case Report. IJMDC. Online First: 22 May, 2026. doi:10.24911/IJMDC.51-1775089334

Web Style

Alkamees S, Alsanad LF, Alanazi R, Albakr F, Almasoud S, Alhelal S. Early-Onset Hidradenitis Suppurativa with DOCK8-Deficiency Hyper-IgE Syndrome: A Pediatric Case Report. https://www.ijmdc.com/?mno=316056 [Access: June 22, 2026]. doi:10.24911/IJMDC.51-1775089334

AMA (American Medical Association) Style

Alkamees S, Alsanad LF, Alanazi R, Albakr F, Almasoud S, Alhelal S. Early-Onset Hidradenitis Suppurativa with DOCK8-Deficiency Hyper-IgE Syndrome: A Pediatric Case Report. IJMDC. Online First: 22 May, 2026. doi:10.24911/IJMDC.51-1775089334

Vancouver/ICMJE Style

Alkamees S, Alsanad LF, Alanazi R, Albakr F, Almasoud S, Alhelal S. Early-Onset Hidradenitis Suppurativa with DOCK8-Deficiency Hyper-IgE Syndrome: A Pediatric Case Report. IJMDC, [cited June 22, 2026]; Online First: 22 May, 2026. doi:10.24911/IJMDC.51-1775089334

Harvard Style

Alkamees, S., Alsanad, . L. F., Alanazi, . R., Albakr, . F., Almasoud, . S. & Alhelal, . S. (0) Early-Onset Hidradenitis Suppurativa with DOCK8-Deficiency Hyper-IgE Syndrome: A Pediatric Case Report. IJMDC, Online First: 22 May, 2026. doi:10.24911/IJMDC.51-1775089334

Turabian Style

Alkamees, Saleh, Layan F Alsanad, Rawan Alanazi, Farah Albakr, Sharifah Almasoud, and Sadeem Alhelal. 0. Early-Onset Hidradenitis Suppurativa with DOCK8-Deficiency Hyper-IgE Syndrome: A Pediatric Case Report. International Journal of Medicine in Developing Countries, Online First: 22 May, 2026. doi:10.24911/IJMDC.51-1775089334

Chicago Style

Alkamees, Saleh, Layan F Alsanad, Rawan Alanazi, Farah Albakr, Sharifah Almasoud, and Sadeem Alhelal. "Early-Onset Hidradenitis Suppurativa with DOCK8-Deficiency Hyper-IgE Syndrome: A Pediatric Case Report." International Journal of Medicine in Developing Countries Online First: 22 May, 2026. doi:10.24911/IJMDC.51-1775089334

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Alkamees, S., Alsanad, . L. F., Alanazi, . R., Albakr, . F., Almasoud, . S. & Alhelal, . S. (0) Early-Onset Hidradenitis Suppurativa with DOCK8-Deficiency Hyper-IgE Syndrome: A Pediatric Case Report. International Journal of Medicine in Developing Countries, Online First: 22 May, 2026. doi:10.24911/IJMDC.51-1775089334

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