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2026, Vol: 10, Issue: 9
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Review Article
Online Published: 26 Sep 2026
 


Association between skin fungal infections and psoriasis: systematic review

Turki Saeed Alkahtani, Sarah Saad Alamer, Abdulaziz Ahmed Alomari, Suliman Khalid Alkhudairy, Fahad Mansour Alrowili, Hanan Almeshal.


Abstract
Psoriasis, a chronic immune-mediated inflammatory skin disease, has been increasingly associated with fungal infections, though the nature of this relationship remains unclear. Fungal pathogens such as Malassezia, Candida, and dermatophytes might contribute to disease exacerbation, particularly in patients undergoing immunomodulatory therapies. This systematic review aimed to examine the association between skin fungal infections and psoriasis, focusing on prevalence, risk factors, and the impact of treatments. Following PRISMA guidelines, a comprehensive literature search was conducted across PubMed, Web of Science, Scopus, and Science Direct. Studies investigating fungal infections in psoriasis patients were included, while reviews and non-English publications were excluded. Data on prevalence, risk factors, and treatment effects were extracted and qualitatively synthesized. Five studies (n=950 patients) were included, revealing fungal infection prevalence ranging from 12% to 47%. Malassezia colonization in scalp psoriasis was reduced by IL-17 inhibitors. Onychomycosis (35.3% prevalence) was linked to diabetes, wet work, and methotrexate use. Higher Candida colonization (47%) in severe psoriasis, mitigated by apremilast. IL-17 inhibitors increased candidiasis risk (12.3%) but reduced Malassezia overgrowth. Fungal infections were found to be prevalent in psoriasis, with risk influenced by disease severity, comorbidities (e.g., diabetes), and treatment type. IL-17 inhibitors exhibited dual effects, suppressing Malassezia while increasing Candida susceptibility. Integrated dermatological and mycological assessments are recommended for optimal management. Further research should explore targeted antifungal strategies in psoriasis therapy.

Key words: Psoriasis, fungal infections, Malassezia, Candida, onychomycosis, IL-17 inhibitors, immunomodulatory therapy, systematic review


 
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How to Cite this Article
Pubmed Style

Alkahtani TS, Alamer SS, Alomari AA, Alkhudairy SK, Alrowili FM, Almeshal H. Association between skin fungal infections and psoriasis: systematic review. IJMDC. Online First: 26 Sep, 2026. doi:10.24911/IJMDC.51-1780538078

Web Style

Alkahtani TS, Alamer SS, Alomari AA, Alkhudairy SK, Alrowili FM, Almeshal H. Association between skin fungal infections and psoriasis: systematic review. https://www.ijmdc.com/?mno=323171 [Access: September 26, 2026]. doi:10.24911/IJMDC.51-1780538078

AMA (American Medical Association) Style

Alkahtani TS, Alamer SS, Alomari AA, Alkhudairy SK, Alrowili FM, Almeshal H. Association between skin fungal infections and psoriasis: systematic review. IJMDC. Online First: 26 Sep, 2026. doi:10.24911/IJMDC.51-1780538078


Vancouver/ICMJE Style

Alkahtani TS, Alamer SS, Alomari AA, Alkhudairy SK, Alrowili FM, Almeshal H. Association between skin fungal infections and psoriasis: systematic review. IJMDC, [cited September 26, 2026]; Online First: 26 Sep, 2026. doi:10.24911/IJMDC.51-1780538078


Harvard Style

Alkahtani, T. S., Alamer, . S. S., Alomari, . A. A., Alkhudairy, . S. K., Alrowili, . F. M. & Almeshal, . H. (2026) Association between skin fungal infections and psoriasis: systematic review. IJMDC, Online First: 26 Sep, 2026. doi:10.24911/IJMDC.51-1780538078


Turabian Style

Alkahtani, Turki Saeed, Sarah Saad Alamer, Abdulaziz Ahmed Alomari, Suliman Khalid Alkhudairy, Fahad Mansour Alrowili, and Hanan Almeshal. 2026. Association between skin fungal infections and psoriasis: systematic review. International Journal of Medicine in Developing Countries, Online First: 26 Sep, 2026. doi:10.24911/IJMDC.51-1780538078


Chicago Style

Alkahtani, Turki Saeed, Sarah Saad Alamer, Abdulaziz Ahmed Alomari, Suliman Khalid Alkhudairy, Fahad Mansour Alrowili, and Hanan Almeshal. "Association between skin fungal infections and psoriasis: systematic review." International Journal of Medicine in Developing Countries Online First: 26 Sep, 2026. doi:10.24911/IJMDC.51-1780538078


MLA (The Modern Language Association) Style

Alkahtani, Turki Saeed, Sarah Saad Alamer, Abdulaziz Ahmed Alomari, Suliman Khalid Alkhudairy, Fahad Mansour Alrowili, and Hanan Almeshal. "Association between skin fungal infections and psoriasis: systematic review." International Journal of Medicine in Developing Countries Online First: 26 Sep, 2026. Web. 26 Sep 2026 doi:10.24911/IJMDC.51-1780538078


APA (American Psychological Association) Style

Alkahtani, T. S., Alamer, . S. S., Alomari, . A. A., Alkhudairy, . S. K., Alrowili, . F. M. & Almeshal, . H. (2026) Association between skin fungal infections and psoriasis: systematic review. International Journal of Medicine in Developing Countries, Online First: 26 Sep, 2026. doi:10.24911/IJMDC.51-1780538078




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    About International Journal of Medicine in Developing Countries

    International Journal of Medicine in Developing Countries is a peer-reviewed, open-access international medical journal. Journal Title Internat ... Read more.



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