Effect of Intravenous Fluid Therapy in Managing Acute Painful Crises in Sickle Cell Disease Patients

Mohammed AlShahrani; Sara Alahmadi; Alhanouf Rayyani; Salma Alkhabbaz; Norah Aljalal; Hawra Alatooq; Manal Farhan; Fatimah Altuwailib

doi:10.24911/IJMDC.51-1702814683

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Original Article

Online Publishing Date:
07 / 01 / 2024

IJMDC. 2024; 8(2): 655-659

doi: 10.24911/IJMDC.51-1702814683

Effect of Intravenous Fluid Therapy in Managing Acute Painful Crises in Sickle Cell Disease Patients

Mohammed AlShahrani, Sara Alahmadi, Alhanouf Rayyani, Salma Alkhabbaz, Norah Aljalal, Hawra Alatooq, Manal Farhan, Fatimah Altuwailib.

Abstract
Background: Sickle cell disease (SCD), an autosomal recessive mutation leading to alterations in the shape of red blood cells, compromises their oxygen-carrying capacity, and is prevalent in Saudi Arabia. Individuals with SCD experience vaso-occlusive crises, leading to severe pain episodes. Although fluid administration is a common practice to deter the sickling process, limited data exist on its efficacy.
Method: This substudy was preplanned within the published randomized control trial titled "Ketamine Administration for Acute Painful Sickle Cell Crisis: A Randomized Controlled Trial," conducted at King Fahad University Hospital in Saudi Arabia in 2019.
Results: The analysis included 139 patients. Both arms received equal amounts and types of analgesics, with 51.7% receiving up to 500 ml intravenous fluid and 48.3% receiving more than 500 ml. Of the participants, 23.7% were admitted to the hospital, while 76.3% were discharged. The average length of stay in the emergency department (ED) was 4.6 ± 2.1 hours. There was no significant difference in the average pain score between the arms at 30-120 minutes. However, patients who received more fluid (> 500 ml) exhibited a higher admission rate and a longer ED stay.
Conclusions: The amount of fluid administered to SCD patients in the emergency department during a vaso-occlusive crisis did not show a significant difference in pain score improvement. Notably, patients receiving more fluid demonstrated longer ED stays and higher admission rates.

Key words: Sickle cell disease, intravenous fluid, vaso-occlusive crises, painful crises, pain management

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Pubmed Style

AlShahrani M, Alahmadi S, Rayyani A, Alkhabbaz S, Aljalal N, Alatooq H, Farhan M, Altuwailib F. Effect of Intravenous Fluid Therapy in Managing Acute Painful Crises in Sickle Cell Disease Patients. IJMDC. 2024; 8(2): 655-659. doi:10.24911/IJMDC.51-1702814683

Web Style

AlShahrani M, Alahmadi S, Rayyani A, Alkhabbaz S, Aljalal N, Alatooq H, Farhan M, Altuwailib F. Effect of Intravenous Fluid Therapy in Managing Acute Painful Crises in Sickle Cell Disease Patients. https://www.ijmdc.com/?mno=181630 [Access: May 13, 2024]. doi:10.24911/IJMDC.51-1702814683

AMA (American Medical Association) Style

AlShahrani M, Alahmadi S, Rayyani A, Alkhabbaz S, Aljalal N, Alatooq H, Farhan M, Altuwailib F. Effect of Intravenous Fluid Therapy in Managing Acute Painful Crises in Sickle Cell Disease Patients. IJMDC. 2024; 8(2): 655-659. doi:10.24911/IJMDC.51-1702814683

Vancouver/ICMJE Style

AlShahrani M, Alahmadi S, Rayyani A, Alkhabbaz S, Aljalal N, Alatooq H, Farhan M, Altuwailib F. Effect of Intravenous Fluid Therapy in Managing Acute Painful Crises in Sickle Cell Disease Patients. IJMDC. (2024), [cited May 13, 2024]; 8(2): 655-659. doi:10.24911/IJMDC.51-1702814683

Harvard Style

AlShahrani, M., Alahmadi, . S., Rayyani, . A., Alkhabbaz, . S., Aljalal, . N., Alatooq, . H., Farhan, . M. & Altuwailib, . F. (2024) Effect of Intravenous Fluid Therapy in Managing Acute Painful Crises in Sickle Cell Disease Patients. IJMDC, 8 (2), 655-659. doi:10.24911/IJMDC.51-1702814683

Turabian Style

AlShahrani, Mohammed, Sara Alahmadi, Alhanouf Rayyani, Salma Alkhabbaz, Norah Aljalal, Hawra Alatooq, Manal Farhan, and Fatimah Altuwailib. 2024. Effect of Intravenous Fluid Therapy in Managing Acute Painful Crises in Sickle Cell Disease Patients. International Journal of Medicine in Developing Countries, 8 (2), 655-659. doi:10.24911/IJMDC.51-1702814683

Chicago Style

AlShahrani, Mohammed, Sara Alahmadi, Alhanouf Rayyani, Salma Alkhabbaz, Norah Aljalal, Hawra Alatooq, Manal Farhan, and Fatimah Altuwailib. "Effect of Intravenous Fluid Therapy in Managing Acute Painful Crises in Sickle Cell Disease Patients." International Journal of Medicine in Developing Countries 8 (2024), 655-659. doi:10.24911/IJMDC.51-1702814683

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

AlShahrani, M., Alahmadi, . S., Rayyani, . A., Alkhabbaz, . S., Aljalal, . N., Alatooq, . H., Farhan, . M. & Altuwailib, . F. (2024) Effect of Intravenous Fluid Therapy in Managing Acute Painful Crises in Sickle Cell Disease Patients. International Journal of Medicine in Developing Countries, 8 (2), 655-659. doi:10.24911/IJMDC.51-1702814683

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