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Review Article
Online Published: 25 Nov 2024
 


Assessment of the efficacy of intravitreal ranibizumab compared to laser treatment in retinopathy of prematurity: a systematic review and meta-analysis

Muhammad Abdullah Tufal, Sultan F. Al-hawas, Jomanah Khalid Aljohani, Asma Mubarak Alqahtani, Njood Mohammad Alhajri, Shaden Mohammed Alhazmi, Alwaleed Abdulhadi Alqahtani, Sharooq Abduljalil Alameer, Aseel Abdulaziz Alrefaei, Mohammed Abdulhameed Alelaiwi, Abdulrahman Saleh Alghamdi.


Abstract
Retinopathy of prematurity (ROP) is a retinal disorder that affects premature infants and is defined by aberrant retinal blood vessel proliferation. One of the first therapies for ROP was laser therapy. Intravitreal ranibizumab (IVR) is a recently advanced therapy that can reverse neovascularization and increase retinal stability. This systematic review and meta-analysis aimed to assess and compare the efficacy of IVR and laser treatment for ROP management. Online search was carried out using four databases including PubMed, Cochrane Central Register of Controlled Trials, Scopus, and Ovid. No search filters were used, and the search encompassed the period from inception till September 2024. The search terms included “intravitreal ranibizumab” AND “retinopathy of prematurity” AND “laser treatment”. The systematic review selection process started with the identification of 128 records. After removing duplicates and screening the titles and abstracts, five studies were included in the final review and analysis. This meta-analysis demonstrated that while IVR is effective in treating ROP and potentially preserves peripheral retina, it is associated with a higher recurrence rate in comparison to laser therapy. Laser therapy remains a robust option with lower recurrence rates, though it might impact peripheral vision. The combination of IVR with other modalities, such as zone I sparing laser treatment or photocoagulation, as suggested by recent studies, might offer a balanced approach that addresses both disease management and retinal preservation. Such combined strategies could help mitigate recurrence and improve long-term outcomes.

Key words: Efficacy, intravitreal ranibizumab (IVR), laser treatment, retinopathy of prematurity (ROP), systematic review


 
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How to Cite this Article
Pubmed Style

Tufal MA, Al-hawas SF, Aljohani JK, Alqahtani AM, Alhajri NM, Alhazmi SM, Alqahtani AA, Alameer SA, Alrefaei AA, Alelaiwi MA, Alghamdi AS. Assessment of the efficacy of intravitreal ranibizumab compared to laser treatment in retinopathy of prematurity: a systematic review and meta-analysis. IJMDC. 2024; 8(10): 2878-2885. doi:10.24911/IJMDC.51-1728729021

Web Style

Tufal MA, Al-hawas SF, Aljohani JK, Alqahtani AM, Alhajri NM, Alhazmi SM, Alqahtani AA, Alameer SA, Alrefaei AA, Alelaiwi MA, Alghamdi AS. Assessment of the efficacy of intravitreal ranibizumab compared to laser treatment in retinopathy of prematurity: a systematic review and meta-analysis. https://www.ijmdc.com/?mno=224345 [Access: October 14, 2025]. doi:10.24911/IJMDC.51-1728729021

AMA (American Medical Association) Style

Tufal MA, Al-hawas SF, Aljohani JK, Alqahtani AM, Alhajri NM, Alhazmi SM, Alqahtani AA, Alameer SA, Alrefaei AA, Alelaiwi MA, Alghamdi AS. Assessment of the efficacy of intravitreal ranibizumab compared to laser treatment in retinopathy of prematurity: a systematic review and meta-analysis. IJMDC. 2024; 8(10): 2878-2885. doi:10.24911/IJMDC.51-1728729021


Vancouver/ICMJE Style

Tufal MA, Al-hawas SF, Aljohani JK, Alqahtani AM, Alhajri NM, Alhazmi SM, Alqahtani AA, Alameer SA, Alrefaei AA, Alelaiwi MA, Alghamdi AS. Assessment of the efficacy of intravitreal ranibizumab compared to laser treatment in retinopathy of prematurity: a systematic review and meta-analysis. IJMDC. (2024), [cited October 14, 2025]; 8(10): 2878-2885. doi:10.24911/IJMDC.51-1728729021


Harvard Style

Tufal, M. A., Al-hawas, . S. F., Aljohani, . J. K., Alqahtani, . A. M., Alhajri, . N. M., Alhazmi, . S. M., Alqahtani, . A. A., Alameer, . S. A., Alrefaei, . A. A., Alelaiwi, . M. A. & Alghamdi, . A. S. (2024) Assessment of the efficacy of intravitreal ranibizumab compared to laser treatment in retinopathy of prematurity: a systematic review and meta-analysis. IJMDC, 8 (10), 2878-2885. doi:10.24911/IJMDC.51-1728729021


Turabian Style

Tufal, Muhammad Abdullah, Sultan F. Al-hawas, Jomanah Khalid Aljohani, Asma Mubarak Alqahtani, Njood Mohammad Alhajri, Shaden Mohammed Alhazmi, Alwaleed Abdulhadi Alqahtani, Sharooq Abduljalil Alameer, Aseel Abdulaziz Alrefaei, Mohammed Abdulhameed Alelaiwi, and Abdulrahman Saleh Alghamdi. 2024. Assessment of the efficacy of intravitreal ranibizumab compared to laser treatment in retinopathy of prematurity: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 8 (10), 2878-2885. doi:10.24911/IJMDC.51-1728729021


Chicago Style

Tufal, Muhammad Abdullah, Sultan F. Al-hawas, Jomanah Khalid Aljohani, Asma Mubarak Alqahtani, Njood Mohammad Alhajri, Shaden Mohammed Alhazmi, Alwaleed Abdulhadi Alqahtani, Sharooq Abduljalil Alameer, Aseel Abdulaziz Alrefaei, Mohammed Abdulhameed Alelaiwi, and Abdulrahman Saleh Alghamdi. "Assessment of the efficacy of intravitreal ranibizumab compared to laser treatment in retinopathy of prematurity: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 8 (2024), 2878-2885. doi:10.24911/IJMDC.51-1728729021


MLA (The Modern Language Association) Style

Tufal, Muhammad Abdullah, Sultan F. Al-hawas, Jomanah Khalid Aljohani, Asma Mubarak Alqahtani, Njood Mohammad Alhajri, Shaden Mohammed Alhazmi, Alwaleed Abdulhadi Alqahtani, Sharooq Abduljalil Alameer, Aseel Abdulaziz Alrefaei, Mohammed Abdulhameed Alelaiwi, and Abdulrahman Saleh Alghamdi. "Assessment of the efficacy of intravitreal ranibizumab compared to laser treatment in retinopathy of prematurity: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 8.10 (2024), 2878-2885. Print. doi:10.24911/IJMDC.51-1728729021


APA (American Psychological Association) Style

Tufal, M. A., Al-hawas, . S. F., Aljohani, . J. K., Alqahtani, . A. M., Alhajri, . N. M., Alhazmi, . S. M., Alqahtani, . A. A., Alameer, . S. A., Alrefaei, . A. A., Alelaiwi, . M. A. & Alghamdi, . A. S. (2024) Assessment of the efficacy of intravitreal ranibizumab compared to laser treatment in retinopathy of prematurity: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 8 (10), 2878-2885. doi:10.24911/IJMDC.51-1728729021




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