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Review Article
Online Published: 17 Nov 2024
 


Efficacy and safety of oral propranolol versus sodium valproate in prophylaxis of migraine: a systematic review and meta-analysis

Tariq M. Shaqran, Amirah Abdullah A. Alatawi, Abdulaziz A. Alsuhaibani, Yara Khaled Alghamdi, Aisha T. Alfaraidi, Ghadeer M. Fardan, Reema H. Aljasir, Ashraf Ali Alkinani, Sadeem K. Almulhim, Sara N. Alshakhouri, Maram Ali Albadan, Yasmeen A. Buqahhoos, Maryam Fadhel Mohamed Kadhem.


Abstract
Migraine is a common neurological disorder, and prophylactic medication is often used to reduce the frequency and severity of attacks. Sodium valproate and propranolol are two commonly used medications for migraine prophylaxis, but their comparative efficacy and safety remain debated. The present review aimed at systematically evaluating the available evidence comparing the efficacy and safety of sodium valproate versus propranolol in the prophylaxis of common migraine headaches. A comprehensive search of electronic databases was conducted to identify randomized controlled trials comparing sodium valproate and propranolol for migraine prophylaxis. The primary outcomes were a reduction in headache frequency, severity, and duration. Secondary outcomes included adverse events. Six studies were included in the meta-analysis, involving a total of 383 participants. Overall, the results suggest that there is no significant difference between sodium valproate and propranolol in terms of their efficacy in reducing headache frequency, severity, duration, or achieving total cessation of attacks. This finding holds true for both pediatric and adult patients. Based on the available evidence, this meta-analysis suggests that sodium valproate and propranolol are equally effective in the prophylaxis of migraine headaches. However, further research is needed to confirm these findings and to investigate the long-term effects of these medications.

Key words: Prophylaxis, propranolol, sodium valproate, headache, migraine


 
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How to Cite this Article
Pubmed Style

Shaqran TM, Alatawi AAA, Alsuhaibani AA, Alghamdi YK, Alfaraidi AT, Fardan GM, Aljasir RH, Alkinani AA, Almulhim SK, Alshakhouri SN, Albadan MA, Buqahhoos YA, Kadhem MFM. Efficacy and safety of oral propranolol versus sodium valproate in prophylaxis of migraine: a systematic review and meta-analysis. IJMDC. 2024; 8(10): 2886-2896. doi:10.24911/IJMDC.51-1728900894

Web Style

Shaqran TM, Alatawi AAA, Alsuhaibani AA, Alghamdi YK, Alfaraidi AT, Fardan GM, Aljasir RH, Alkinani AA, Almulhim SK, Alshakhouri SN, Albadan MA, Buqahhoos YA, Kadhem MFM. Efficacy and safety of oral propranolol versus sodium valproate in prophylaxis of migraine: a systematic review and meta-analysis. https://www.ijmdc.com/?mno=224541 [Access: April 22, 2025]. doi:10.24911/IJMDC.51-1728900894

AMA (American Medical Association) Style

Shaqran TM, Alatawi AAA, Alsuhaibani AA, Alghamdi YK, Alfaraidi AT, Fardan GM, Aljasir RH, Alkinani AA, Almulhim SK, Alshakhouri SN, Albadan MA, Buqahhoos YA, Kadhem MFM. Efficacy and safety of oral propranolol versus sodium valproate in prophylaxis of migraine: a systematic review and meta-analysis. IJMDC. 2024; 8(10): 2886-2896. doi:10.24911/IJMDC.51-1728900894


Vancouver/ICMJE Style

Shaqran TM, Alatawi AAA, Alsuhaibani AA, Alghamdi YK, Alfaraidi AT, Fardan GM, Aljasir RH, Alkinani AA, Almulhim SK, Alshakhouri SN, Albadan MA, Buqahhoos YA, Kadhem MFM. Efficacy and safety of oral propranolol versus sodium valproate in prophylaxis of migraine: a systematic review and meta-analysis. IJMDC. (2024), [cited April 22, 2025]; 8(10): 2886-2896. doi:10.24911/IJMDC.51-1728900894


Harvard Style

Shaqran, T. M., Alatawi, . A. A. A., Alsuhaibani, . A. A., Alghamdi, . Y. K., Alfaraidi, . A. T., Fardan, . G. M., Aljasir, . R. H., Alkinani, . A. A., Almulhim, . S. K., Alshakhouri, . S. N., Albadan, . M. A., Buqahhoos, . Y. A. & Kadhem, . M. F. M. (2024) Efficacy and safety of oral propranolol versus sodium valproate in prophylaxis of migraine: a systematic review and meta-analysis. IJMDC, 8 (10), 2886-2896. doi:10.24911/IJMDC.51-1728900894


Turabian Style

Shaqran, Tariq M., Amirah Abdullah A. Alatawi, Abdulaziz A. Alsuhaibani, Yara Khaled Alghamdi, Aisha T. Alfaraidi, Ghadeer M. Fardan, Reema H. Aljasir, Ashraf Ali Alkinani, Sadeem K. Almulhim, Sara N. Alshakhouri, Maram Ali Albadan, Yasmeen A. Buqahhoos, and Maryam Fadhel Mohamed Kadhem. 2024. Efficacy and safety of oral propranolol versus sodium valproate in prophylaxis of migraine: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 8 (10), 2886-2896. doi:10.24911/IJMDC.51-1728900894


Chicago Style

Shaqran, Tariq M., Amirah Abdullah A. Alatawi, Abdulaziz A. Alsuhaibani, Yara Khaled Alghamdi, Aisha T. Alfaraidi, Ghadeer M. Fardan, Reema H. Aljasir, Ashraf Ali Alkinani, Sadeem K. Almulhim, Sara N. Alshakhouri, Maram Ali Albadan, Yasmeen A. Buqahhoos, and Maryam Fadhel Mohamed Kadhem. "Efficacy and safety of oral propranolol versus sodium valproate in prophylaxis of migraine: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 8 (2024), 2886-2896. doi:10.24911/IJMDC.51-1728900894


MLA (The Modern Language Association) Style

Shaqran, Tariq M., Amirah Abdullah A. Alatawi, Abdulaziz A. Alsuhaibani, Yara Khaled Alghamdi, Aisha T. Alfaraidi, Ghadeer M. Fardan, Reema H. Aljasir, Ashraf Ali Alkinani, Sadeem K. Almulhim, Sara N. Alshakhouri, Maram Ali Albadan, Yasmeen A. Buqahhoos, and Maryam Fadhel Mohamed Kadhem. "Efficacy and safety of oral propranolol versus sodium valproate in prophylaxis of migraine: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 8.10 (2024), 2886-2896. Print. doi:10.24911/IJMDC.51-1728900894


APA (American Psychological Association) Style

Shaqran, T. M., Alatawi, . A. A. A., Alsuhaibani, . A. A., Alghamdi, . Y. K., Alfaraidi, . A. T., Fardan, . G. M., Aljasir, . R. H., Alkinani, . A. A., Almulhim, . S. K., Alshakhouri, . S. N., Albadan, . M. A., Buqahhoos, . Y. A. & Kadhem, . M. F. M. (2024) Efficacy and safety of oral propranolol versus sodium valproate in prophylaxis of migraine: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 8 (10), 2886-2896. doi:10.24911/IJMDC.51-1728900894




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