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Review Article
Online Published: 09 Dec 2024
 


The efficacy of Sacituzumab Govitecan in treatment of triple-negative breast cancer: a systematic review and meta-analysis

Elshymaa Elsayed Raslan, Abdulaziz Mohammed Alruzaihan, Khaled Saeed Mohammed Alqahtani, Hind Saleh Alyousef, Atef Eid Alrashidi, Malak Mohammed Nehad Alzaeim, Walaa Jehad Alekri, Hawra Habib Khamis, Sereen Saleem Eid Aljohani, Rawabi Saleh Alamri, Yazeed Ibrahim Almershed, Abdullah Khalid Alsaawi, Shahad Anwar Helmi.


Abstract
Triple-negative breast cancer (TNBC) is the aggressive breast cancer subtype with a bad prognosis. It has been known to lack effective treatment other than non-specific chemotherapy. Antibody-drug conjugates (ADCs) have changed the breast cancer treatment landscape such as Trophoblast cell surface antigen-2 as a target for ADCs. To evaluate sacituzumab govitecan’s efficacy in treating triple-negative breast cancer, the present review searched PubMed/Medline, Clinical Key, EMBASE, ClinicalTrials.gov, and Scopus. The studies included randomized clinical trials (RCTs). The assessment of efficacy was conducted in terms of complete response (CR), partial response (PR), objective response rate (ORR), and clinical benefit rate (CBR). The risk of bias (ROB) was assessed using the revised version of the Cochrane ROB tool. Six eligible RCTs including 861 female patients with TNBC were assessed. The overall random-effects pooled prevalence of CR from the positive outcomes was 0.04 (95% CI: 0.03-0.05, p < 0.001). The partial response (PR) was 0.29 (95% CI: 0.26-0.32 p < 0.001), ORR was 0.29 (95% CI: 0.22-0.36, p < 0.001), and CBR was 0.36 (95% CI: 0.21-0.51, p < 0.001). The results showed that the treatment significantly improved patient outcomes. These findings might help define the efficacy profile of sacituzumab govitecan comprehensively; showing that sacituzumab govitecan is an effective drug in treating TNBC patients and assists in designing future clinical trials.

Key words: Triple-negative breast cancer, Sacituzumab govitecan, antibody-drug conjugate, effectiveness, systemic review


 
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How to Cite this Article
Pubmed Style

Raslan EE, Alruzaihan AM, Alqahtani KSM, Alyousef HS, Alrashidi AE, Alzaeim MMN, Alekri WJ, Khamis HH, Aljohani SSE, Alamri RS, Almershed YI, Alsaawi AK, Helmi SA. The efficacy of Sacituzumab Govitecan in treatment of triple-negative breast cancer: a systematic review and meta-analysis. IJMDC. 2024; 8(10): 2928-2936. doi:10.24911/IJMDC.51-1730800498

Web Style

Raslan EE, Alruzaihan AM, Alqahtani KSM, Alyousef HS, Alrashidi AE, Alzaeim MMN, Alekri WJ, Khamis HH, Aljohani SSE, Alamri RS, Almershed YI, Alsaawi AK, Helmi SA. The efficacy of Sacituzumab Govitecan in treatment of triple-negative breast cancer: a systematic review and meta-analysis. https://www.ijmdc.com/?mno=227475 [Access: March 17, 2025]. doi:10.24911/IJMDC.51-1730800498

AMA (American Medical Association) Style

Raslan EE, Alruzaihan AM, Alqahtani KSM, Alyousef HS, Alrashidi AE, Alzaeim MMN, Alekri WJ, Khamis HH, Aljohani SSE, Alamri RS, Almershed YI, Alsaawi AK, Helmi SA. The efficacy of Sacituzumab Govitecan in treatment of triple-negative breast cancer: a systematic review and meta-analysis. IJMDC. 2024; 8(10): 2928-2936. doi:10.24911/IJMDC.51-1730800498


Vancouver/ICMJE Style

Raslan EE, Alruzaihan AM, Alqahtani KSM, Alyousef HS, Alrashidi AE, Alzaeim MMN, Alekri WJ, Khamis HH, Aljohani SSE, Alamri RS, Almershed YI, Alsaawi AK, Helmi SA. The efficacy of Sacituzumab Govitecan in treatment of triple-negative breast cancer: a systematic review and meta-analysis. IJMDC. (2024), [cited March 17, 2025]; 8(10): 2928-2936. doi:10.24911/IJMDC.51-1730800498


Harvard Style

Raslan, E. E., Alruzaihan, . A. M., Alqahtani, . K. S. M., Alyousef, . H. S., Alrashidi, . A. E., Alzaeim, . M. M. N., Alekri, . W. J., Khamis, . H. H., Aljohani, . S. S. E., Alamri, . R. S., Almershed, . Y. I., Alsaawi, . A. K. & Helmi, . S. A. (2024) The efficacy of Sacituzumab Govitecan in treatment of triple-negative breast cancer: a systematic review and meta-analysis. IJMDC, 8 (10), 2928-2936. doi:10.24911/IJMDC.51-1730800498


Turabian Style

Raslan, Elshymaa Elsayed, Abdulaziz Mohammed Alruzaihan, Khaled Saeed Mohammed Alqahtani, Hind Saleh Alyousef, Atef Eid Alrashidi, Malak Mohammed Nehad Alzaeim, Walaa Jehad Alekri, Hawra Habib Khamis, Sereen Saleem Eid Aljohani, Rawabi Saleh Alamri, Yazeed Ibrahim Almershed, Abdullah Khalid Alsaawi, and Shahad Anwar Helmi. 2024. The efficacy of Sacituzumab Govitecan in treatment of triple-negative breast cancer: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 8 (10), 2928-2936. doi:10.24911/IJMDC.51-1730800498


Chicago Style

Raslan, Elshymaa Elsayed, Abdulaziz Mohammed Alruzaihan, Khaled Saeed Mohammed Alqahtani, Hind Saleh Alyousef, Atef Eid Alrashidi, Malak Mohammed Nehad Alzaeim, Walaa Jehad Alekri, Hawra Habib Khamis, Sereen Saleem Eid Aljohani, Rawabi Saleh Alamri, Yazeed Ibrahim Almershed, Abdullah Khalid Alsaawi, and Shahad Anwar Helmi. "The efficacy of Sacituzumab Govitecan in treatment of triple-negative breast cancer: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 8 (2024), 2928-2936. doi:10.24911/IJMDC.51-1730800498


MLA (The Modern Language Association) Style

Raslan, Elshymaa Elsayed, Abdulaziz Mohammed Alruzaihan, Khaled Saeed Mohammed Alqahtani, Hind Saleh Alyousef, Atef Eid Alrashidi, Malak Mohammed Nehad Alzaeim, Walaa Jehad Alekri, Hawra Habib Khamis, Sereen Saleem Eid Aljohani, Rawabi Saleh Alamri, Yazeed Ibrahim Almershed, Abdullah Khalid Alsaawi, and Shahad Anwar Helmi. "The efficacy of Sacituzumab Govitecan in treatment of triple-negative breast cancer: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 8.10 (2024), 2928-2936. Print. doi:10.24911/IJMDC.51-1730800498


APA (American Psychological Association) Style

Raslan, E. E., Alruzaihan, . A. M., Alqahtani, . K. S. M., Alyousef, . H. S., Alrashidi, . A. E., Alzaeim, . M. M. N., Alekri, . W. J., Khamis, . H. H., Aljohani, . S. S. E., Alamri, . R. S., Almershed, . Y. I., Alsaawi, . A. K. & Helmi, . S. A. (2024) The efficacy of Sacituzumab Govitecan in treatment of triple-negative breast cancer: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 8 (10), 2928-2936. doi:10.24911/IJMDC.51-1730800498




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