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2025, Vol: 9, Issue: 12
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Review Article
Online Published: 21 Sep 2025
 


Evaluating the impact of moxibustion on pain management in rheumatoid arthritis patients: a systematic review and meta-analysis

Taif Al Qahtani, Lubna Ladnah, Saud Alamri, Mohammed Alshuwaykhat, Jumanah Arafi, Danah Alanazi, Turki Alotaibe, Htoon Alawwad, Hanan Almalki.


Abstract
Rheumatoid arthritis (RA) is a chronic form of autoimmune disease that is distinguished by systemic manifestations, persistent joint inflammation, and the production of autoantibodies. Disease-modifying antirheumatic drugs (DMARDs), nonsteroidal anti-inflammatory drugs (NSAIDs), and corticosteroids are frequently employed to alleviate symptoms and delay the progression of the disease. Nevertheless, the inadequate efficacy of these remedies has prompted the investigation of alternative therapies, such as moxibustion. The objective of this investigation was to evaluate the efficacy of moxibustion in the management of RA. A comprehensive systematic review and meta-analysis (SRMA) was conducted in adherence to the PRISMA guideline to evaluate the effectiveness of moxibustion in the management of RA. A comprehensive search was conducted on Google Scholar and Medline (PubMed). Information on inflammatory markers, rheumatoid factor levels, morning rigidity, disease activity (DAS28 scores), and pain intensity was extracted and analyzed. Three RCTs with 164 RA patients met the inclusion criteria. Moxibustion significantly reduced pain (p-value= 0.01), DAS28 scores (p<0.0001), and morning stiffness duration (p<0.00001), but had no meaningful impact on rheumatoid factor (p-value=0.43), erythrocyte sedimentation rate (ESR) (p-value=0.16), or C-reactive protein (CRP) (p-value=0.66). Moxibustion therapy offers significant clinical benefits for patients with rheumatoid arthritis, including pain reduction, improved disease activity, and alleviation of symptoms such as morning stiffness. These observations suggest that moxibustion can be a valuable complementary therapy for managing rheumatoid arthritis. However, further research, including larger randomized controlled trials and prospective cohort studies, is needed to verify its long-term effectiveness, validate these observations, and explore its broader clinical applications.

Key words: Rheumatoid arthritis, moxibustion, pain intensity, morning stiffness, systematic review


 
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Pubmed Style

Qahtani TA, Ladnah L, Alamri S, Alshuwaykhat M, Arafi J, Alanazi D, Alotaibe T, Alawwad H, Almalki H. Evaluating the impact of moxibustion on pain management in rheumatoid arthritis patients: a systematic review and meta-analysis. IJMDC. Online First: 21 Sep, 2025. doi:10.24911/IJMDC.51-1755082408

Web Style

Qahtani TA, Ladnah L, Alamri S, Alshuwaykhat M, Arafi J, Alanazi D, Alotaibe T, Alawwad H, Almalki H. Evaluating the impact of moxibustion on pain management in rheumatoid arthritis patients: a systematic review and meta-analysis. https://www.ijmdc.com/?mno=277081 [Access: October 12, 2025]. doi:10.24911/IJMDC.51-1755082408

AMA (American Medical Association) Style

Qahtani TA, Ladnah L, Alamri S, Alshuwaykhat M, Arafi J, Alanazi D, Alotaibe T, Alawwad H, Almalki H. Evaluating the impact of moxibustion on pain management in rheumatoid arthritis patients: a systematic review and meta-analysis. IJMDC. Online First: 21 Sep, 2025. doi:10.24911/IJMDC.51-1755082408


Vancouver/ICMJE Style

Qahtani TA, Ladnah L, Alamri S, Alshuwaykhat M, Arafi J, Alanazi D, Alotaibe T, Alawwad H, Almalki H. Evaluating the impact of moxibustion on pain management in rheumatoid arthritis patients: a systematic review and meta-analysis. IJMDC, [cited October 12, 2025]; Online First: 21 Sep, 2025. doi:10.24911/IJMDC.51-1755082408


Harvard Style

Qahtani, T. A., Ladnah, . L., Alamri, . S., Alshuwaykhat, . M., Arafi, . J., Alanazi, . D., Alotaibe, . T., Alawwad, . H. & Almalki, . H. (2025) Evaluating the impact of moxibustion on pain management in rheumatoid arthritis patients: a systematic review and meta-analysis. IJMDC, Online First: 21 Sep, 2025. doi:10.24911/IJMDC.51-1755082408


Turabian Style

Qahtani, Taif Al, Lubna Ladnah, Saud Alamri, Mohammed Alshuwaykhat, Jumanah Arafi, Danah Alanazi, Turki Alotaibe, Htoon Alawwad, and Hanan Almalki. 2025. Evaluating the impact of moxibustion on pain management in rheumatoid arthritis patients: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, Online First: 21 Sep, 2025. doi:10.24911/IJMDC.51-1755082408


Chicago Style

Qahtani, Taif Al, Lubna Ladnah, Saud Alamri, Mohammed Alshuwaykhat, Jumanah Arafi, Danah Alanazi, Turki Alotaibe, Htoon Alawwad, and Hanan Almalki. "Evaluating the impact of moxibustion on pain management in rheumatoid arthritis patients: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries Online First: 21 Sep, 2025. doi:10.24911/IJMDC.51-1755082408


MLA (The Modern Language Association) Style

Qahtani, Taif Al, Lubna Ladnah, Saud Alamri, Mohammed Alshuwaykhat, Jumanah Arafi, Danah Alanazi, Turki Alotaibe, Htoon Alawwad, and Hanan Almalki. "Evaluating the impact of moxibustion on pain management in rheumatoid arthritis patients: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries Online First: 21 Sep, 2025. Web. 12 Oct 2025 doi:10.24911/IJMDC.51-1755082408


APA (American Psychological Association) Style

Qahtani, T. A., Ladnah, . L., Alamri, . S., Alshuwaykhat, . M., Arafi, . J., Alanazi, . D., Alotaibe, . T., Alawwad, . H. & Almalki, . H. (2025) Evaluating the impact of moxibustion on pain management in rheumatoid arthritis patients: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, Online First: 21 Sep, 2025. doi:10.24911/IJMDC.51-1755082408




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