E-ISSN 1658-7820
 
2026, Vol: 10, Issue: 1
10 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Review Article
Online Published: 12 Jan 2026
 


A systematic review on the efficacy of SGLT2 inhibitors in heart failure with reduced and preserved ejection fraction

Safi Abdullah Albeladi, Turki Dhaifallah Albeladi, Mohammed Fahad Albariqi, Sulaiman Shakir Alkayal, Abdullah Hasan Mahallawi, Batool Fawaz Albeladi, Sultanah Ammar Naitah, Manar Mohammed Almohamadi, Yasser Redha Albeladi.


Abstract
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are cornerstone therapy in heart failure (HF), but their relative effectiveness across the ejection fraction (EF) spectrum is uncertain. This was a systematic review after the PRISMA 2020 guidelines were applied to guide the assessment. From database inception to 2025, in-depth searches was conducted through PubMed/MEDLINE and Web of Science, Cochrane CENTRAL, and Google Scholar. Randomized controlled trials (RCTs) and comparative observational studies assessing the efficacy and safety of SGLT2 inhibitors in HF with reduced or preserved EF were included. Risk of bias was assessed using the Cochrane RoB 2.0 tool for RCTs and ROBINS-I for non-randomized studies. Of 1,306 identified records, 15 studies met the inclusion criteria, encompassing over 1.5 million participants. Across trials and real-world cohorts, SGLT2 inhibitors significantly reduced heart failure hospitalizations by 20–30% and cardiovascular death by up to 25%, with benefits observed regardless of diabetes status or EF category. Empagliflozin and dapagliflozin consistently improved composite cardiovascular outcomes, renal function, and quality of life, while adverse events were mild and infrequent. Empagliflozin showed slightly greater effects on ventricular remodeling than dapagliflozin. Most RCTs demonstrated moderate quality with unclear blinding risk; non-randomized studies showed variable but generally low to moderate bias. SGLT2 inhibitors provided consistent cardio-renal benefits and reduced hospitalization and mortality risks across the HF spectrum. Their favorable safety profile supports early integration into guideline-directed therapy for both HFrEF and HFpEF patients.

Key words: SGLT2 inhibitors, heart failure, ejection fraction, cardiovascular outcomes, PRISMA.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Safi Abdullah Albeladi
Articles by Turki Dhaifallah Albeladi
Articles by Mohammed Fahad Albariqi
Articles by Sulaiman Shakir Alkayal
Articles by Abdullah Hasan Mahallawi
Articles by Batool Fawaz Albeladi
Articles by Sultanah Ammar Naitah
Articles by Manar Mohammed Almohamadi
Articles by Yasser Redha Albeladi
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Albeladi SA, Albeladi TD, Albariqi MF, Alkayal SS, Mahallawi AH, Albeladi BF, Naitah SA, Almohamadi MM, Albeladi YR. A systematic review on the efficacy of SGLT2 inhibitors in heart failure with reduced and preserved ejection fraction. IJMDC. 2026; 10(1): 341-350. doi:10.24911/IJMDC.51-1764168665

Web Style

Albeladi SA, Albeladi TD, Albariqi MF, Alkayal SS, Mahallawi AH, Albeladi BF, Naitah SA, Almohamadi MM, Albeladi YR. A systematic review on the efficacy of SGLT2 inhibitors in heart failure with reduced and preserved ejection fraction. https://www.ijmdc.com/?mno=299610 [Access: January 25, 2026]. doi:10.24911/IJMDC.51-1764168665

AMA (American Medical Association) Style

Albeladi SA, Albeladi TD, Albariqi MF, Alkayal SS, Mahallawi AH, Albeladi BF, Naitah SA, Almohamadi MM, Albeladi YR. A systematic review on the efficacy of SGLT2 inhibitors in heart failure with reduced and preserved ejection fraction. IJMDC. 2026; 10(1): 341-350. doi:10.24911/IJMDC.51-1764168665


Vancouver/ICMJE Style

Albeladi SA, Albeladi TD, Albariqi MF, Alkayal SS, Mahallawi AH, Albeladi BF, Naitah SA, Almohamadi MM, Albeladi YR. A systematic review on the efficacy of SGLT2 inhibitors in heart failure with reduced and preserved ejection fraction. IJMDC. (2026), [cited January 25, 2026]; 10(1): 341-350. doi:10.24911/IJMDC.51-1764168665


Harvard Style

Albeladi, S. A., Albeladi, . T. D., Albariqi, . M. F., Alkayal, . S. S., Mahallawi, . A. H., Albeladi, . B. F., Naitah, . S. A., Almohamadi, . M. M. & Albeladi, . Y. R. (2026) A systematic review on the efficacy of SGLT2 inhibitors in heart failure with reduced and preserved ejection fraction. IJMDC, 10 (1), 341-350. doi:10.24911/IJMDC.51-1764168665


Turabian Style

Albeladi, Safi Abdullah, Turki Dhaifallah Albeladi, Mohammed Fahad Albariqi, Sulaiman Shakir Alkayal, Abdullah Hasan Mahallawi, Batool Fawaz Albeladi, Sultanah Ammar Naitah, Manar Mohammed Almohamadi, and Yasser Redha Albeladi. 2026. A systematic review on the efficacy of SGLT2 inhibitors in heart failure with reduced and preserved ejection fraction. International Journal of Medicine in Developing Countries, 10 (1), 341-350. doi:10.24911/IJMDC.51-1764168665


Chicago Style

Albeladi, Safi Abdullah, Turki Dhaifallah Albeladi, Mohammed Fahad Albariqi, Sulaiman Shakir Alkayal, Abdullah Hasan Mahallawi, Batool Fawaz Albeladi, Sultanah Ammar Naitah, Manar Mohammed Almohamadi, and Yasser Redha Albeladi. "A systematic review on the efficacy of SGLT2 inhibitors in heart failure with reduced and preserved ejection fraction." International Journal of Medicine in Developing Countries 10 (2026), 341-350. doi:10.24911/IJMDC.51-1764168665


MLA (The Modern Language Association) Style

Albeladi, Safi Abdullah, Turki Dhaifallah Albeladi, Mohammed Fahad Albariqi, Sulaiman Shakir Alkayal, Abdullah Hasan Mahallawi, Batool Fawaz Albeladi, Sultanah Ammar Naitah, Manar Mohammed Almohamadi, and Yasser Redha Albeladi. "A systematic review on the efficacy of SGLT2 inhibitors in heart failure with reduced and preserved ejection fraction." International Journal of Medicine in Developing Countries 10.1 (2026), 341-350. Print. doi:10.24911/IJMDC.51-1764168665


APA (American Psychological Association) Style

Albeladi, S. A., Albeladi, . T. D., Albariqi, . M. F., Alkayal, . S. S., Mahallawi, . A. H., Albeladi, . B. F., Naitah, . S. A., Almohamadi, . M. M. & Albeladi, . Y. R. (2026) A systematic review on the efficacy of SGLT2 inhibitors in heart failure with reduced and preserved ejection fraction. International Journal of Medicine in Developing Countries, 10 (1), 341-350. doi:10.24911/IJMDC.51-1764168665




Most Viewed Articles
Most Accessed Articles

  • Marginal adaptation of fixed prosthodontics
    Shahad Mohammed Halawani, Sahar Amer Al-Harbi
    IJMDC. 2017; 1(2): 78-84
    » Abstract » doi: 10.24911/IJMDC.1.2.7

  • Parasites in central nervous system
    Amal Ahmed Mohamed, Asmaa Mohamed Mansour
    IJMDC. 2017; 1(2): 72-77
    » Abstract » doi: 10.24911/IJMDC.1.2.6

  • Non-diabetic retinopathy: a case report
    Hassan F. Alkwikbi, Nabil Mamon Abdelfattah, Haithem Mamon Abdelfattah
    IJMDC. 2017; 1(1): 33-37
    » Abstract » doi: 10.24911/IJMDC.1.1.6

  • Vitamin D deficiency among high school female students in Riyadh
    Sahar Mohsen Aldhafeeri, Fatemah Ibraheem Alrawaji, Abrar Mubarak Algharbi, Alanoud Abdullah Alhessan, Ayat Sami Qabaja, Ghaleah Abdulaziz Alnassar, Ghaliah Ofayn Alsulami, Mashael Belal Alrubaian, Norah Abdulaziz Alhatim, Salehah Salih Alotaibi, Zahra Ali Alkhamees
    IJMDC. 2017; 1(1): 18-23
    » Abstract » doi: 10.24911/IJMDC.1.1.4

  • Prognosis of chronic complications of diabetes mellitus (DM) after multiple events of diabetic ketoacidosis (DKA)
    Baraa Faiez Rajab, Anwar Essa Alamrim, Ali Essa Alamri
    IJMDC. 2019; 3(5): 474-479
    » Abstract » doi: 10.24911/IJMDC.51-1546551993

    •
    Most Downloaded
    Top Downloaded Articles

  • Perception and attitude of medical students towards trauma and orthopedic teaching: a cross-sectional study
    Nawaf Hameed Almohammadi, Faisal Ali Almesned, Atif Omar Alhawsah, Sami Aoudah Alahmari, Madloul Jassim Alshammari, Hamad Ali Alkhunayfir
    IJMDC. 2019; 3(6): 503-508
    » Abstract » doi: 10.24911/IJMDC.51-1548706801

  • Anti-IL-17 markedly inhibited the in vitro granuloma induced by Schistosoma mansoni soluble egg antigen.
    Asmaa Ezz, Irene S. Gmail, Fatma Elzahraa H. Salem, Rabab Salama, Soad Nady
    IJMDC. 2018; 2(January 2018): 38-46
    » Abstract » doi: 10.24911/IJMDC.2.1.7

  • Vitamin D deficiency among high school female students in Riyadh
    Sahar Mohsen Aldhafeeri, Fatemah Ibraheem Alrawaji, Abrar Mubarak Algharbi, Alanoud Abdullah Alhessan, Ayat Sami Qabaja, Ghaleah Abdulaziz Alnassar, Ghaliah Ofayn Alsulami, Mashael Belal Alrubaian, Norah Abdulaziz Alhatim, Salehah Salih Alotaibi, Zahra Ali Alkhamees
    IJMDC. 2017; 1(1): 18-23
    » Abstract » doi: 10.24911/IJMDC.1.1.4

  • Antibiotic Resistance Crisis
    Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
    IJMDC. 2019; 3(6): 561-564
    » Abstract » doi: 10.24911/IJMDC.51-1549060699

  • Marginal adaptation of fixed prosthodontics
    Shahad Mohammed Halawani, Sahar Amer Al-Harbi
    IJMDC. 2017; 1(2): 78-84
    » Abstract » doi: 10.24911/IJMDC.1.2.7

    •
    Most Cited Articles
    Most Cited Articles

  • Antibiotic Resistance Crisis
    Nuha Saad Mobarki, Buthaina Abdullah Almerabi, Ahmad Hattan Hattan
    IJMDC. 2019; 3(6): 561-564
    » Abstract » doi: 10.24911/IJMDC.51-1549060699
    Cited : 34 times [Click to see citing articles]

  • Prevalence of depression, anxiety and stress among diabetes mellitus patients in Arar, Northern Saudi Arabia
    AMohammed Elamin Mukrim, Nujud Muteb D. Alshammari, Wurud Muteb D. Alshammari, Maali Subhi T. Alshammari, Yousef Nasif R. Alshammari, Abdulaziz Sael M. Alshammari, Maisa Hamad F. Alanazi, Abdulelah Abdulrhman F. Alzammam, Muharib Mana M. Alshammari, Slwa Khaled Abu Asyah, Aseel Jamal Alzuhayri, Mushref Saeid Alshammari
    IJMDC. 2019; 3(3): 229-233
    » Abstract » doi: 10.24911/IJMDC.51-1542576396
    Cited : 8 times [Click to see citing articles]

  • Knowledge, attitude, and practice of breast self-examination toward breast cancer among female students at King Saud University in Riyadh, Saudi Arabia
    Abdullah Nasser Alomair, Dania Ghazi Felemban, Mohannad Sami Felemban, Jameel Abdullah Awadain, Ammar Saud Altowairqi, Nawaf Fawzan Alfawzan, Fatimah Mohammed Almazayen, Abdulrahman Jalwi Korkoman, Nawaf Saad Alrusayyis
    IJMDC. 2020; 4(2): 429-434
    » Abstract » doi: 10.24911/IJMDC.51-1576668182
    Cited : 8 times [Click to see citing articles]

  • Population awareness about rheumatoid arthritis in Jazan region, Saudi Arabia
    Ahmad Ali Hazzazi, Mohssen Hassen Ageeli, Ahmed Ali Muyidi, Abdulaziz Mohammad Abulgasim, Abdullah Ahmad Yateemi, Nabil Alhakami
    IJMDC. 2020; 4(3): 668-675
    » Abstract » doi: 10.24911/IJMDC.51-1576010943
    Cited : 4 times [Click to see citing articles]

  • Prevalence and factors associated with depression among health care workers in National Guard Hospital in Riyadh, KSA
    Noor Mohammad AlFahhad
    IJMDC. 2018; 2(September 2018): 92-96
    » Abstract » doi: 10.24911/IJMDC.51-1526306040
    Cited : 4 times [Click to see citing articles]

  • Effect of inter-pregnancy interval on pregnancy outcome: a prospective study at Fayoum, Egypt
    Eman M. Mahfouz, Naglaa A. El-Sherbiny, Wafaa Y. Abdel Wahed, Nashwa S. Hamed
    IJMDC. 2018; 2(May 2018): 38-44
    » Abstract » doi: 10.24911/IJMDC.51-1520268317
    Cited : 4 times [Click to see citing articles]

  • Diabetic neuropathy in Saudi Arabia: a comprehensive review for further actions
    Mohammad Mater Aljohani, Amjad Taj Karam, Ayman Abdulaziz Alamri, Mohammed Hamed Manfaloti, Hussain Abbas Alnakhli, Hatem Ahmed Shaqroon
    IJMDC. 2020; 4(11): 2008-2013
    » Abstract » doi: 10.24911/IJMDC.51-1601343665
    Cited : 4 times [Click to see citing articles]

  • Public Awareness of coronary artery disease risk factors in Qassim, Saudi Arabia: a cross-sectional study
    Abdullah Muzil Albadrani, Saleh Sulaiman Al-Ajlan, Abdullah Saer E. Alharbi, Abdulelah Saud Alharbi, Saif Mohammed Radhi Alharbi
    IJMDC. 2020; 4(3): 593-599
    » Abstract » doi: 10.24911/IJMDC.51-1572217065
    Cited : 4 times [Click to see citing articles]

  • Ischemic stroke: prevalence of modifiable risk factors in the Saudi population
    Muhannad Noor Alharbi, Atheer Khalid Alharbi, Mousa Atqan Alamri, Abdulmalik Ayedh Saad Alharthi, Abdulrahman Moneer Alqerafi, Mohamed Noor Alharbi
    IJMDC. 2019; 3(7): 601-603
    » Abstract » doi: 10.24911/IJMDC.51-1548376707
    Cited : 3 times [Click to see citing articles]

  • Prevalence and risk factors for diabetic nephropathy in type 2 diabetic patients, Taif City, Saudi Arabia
    Basel Saad Alzahrani, Turki Hamdan Alzidani, Abdullah Mohammed Alturkistani, Hani Abozaid
    IJMDC. 2019; 3(2): 167-172
    » Abstract » doi: 10.24911/IJMDC.51-1541336905
    Cited : 3 times [Click to see citing articles]

  • Assessment of knowledge and awareness regarding thyroid disorders among Saudi people
    Assem Saleh Ali Almuzaini , Bayan ahmad I Alshareef , Sundos Hamoud O Alghamdi, Ayman Adnan Munshy, Abdulmajeed Khalid M. Aljarallah, Saud Abdulaziz A Salman, Khalid Saud Alroqi, Reem Dayel A Alkhaldi
    IJMDC. 2019; 3(12): 1070-1076
    » Abstract » doi: 10.24911/IJMDC.51-1568037206
    Cited : 3 times [Click to see citing articles]

  • Assessment of knowledge, attitude, and practice in relation to use of isotretinoin among Al-Madinah population, Saudi Arabia
    Amr Molla, Hassan Abdullah Alrizqi, Emtinan Mohammed Salem Alruhaili, Saad Abdullah Alrizqi, Arwa Musaad Alsubhi
    IJMDC. 2020; 4(1): 107-112
    » Abstract » doi: 10.24911/IJMDC.51-1571752077
    Cited : 3 times [Click to see citing articles]

  • Ethical considerations in doctors & pharmaceutical industries relationship: a narrative review
    Mohammed Saud Almasri, Yousef Rafat Bukhari, Bandar Saleh Alzuair, Mansour Khalid Almadi, Amro Khalid Bin Abdulrahman
    IJMDC. 2020; 4(1): 244-252
    » Abstract » doi: 10.24911/IJMDC.51-1572794591
    Cited : 3 times [Click to see citing articles]

  • Assessment of the knowledge of pregnant women regarding the effects of GDM on mothers and neonates at a Maternal and Children hospital in Najran, Saudi Arabia
    Amina Abdo Salhi, Medical Intern, Majed Saeed Alshahrani, Maram Mohammed Alyamin, Waad Ahmed Hamdi, Sarah Raja Alyami, Albatool Saleh Almagbool, Nujoud Hamad Almoqati, Seham Hamad Almoqati, Esra'a Amer Nasser Al-Saaed, Hessa Salem Al Habes, Batool Mubarak Abdullah Alwdei, Ahlam Yhya Saeed Alyami, Wesal Ahmed Alassiri
    IJMDC. 2019; 3(4): 370-375
    » Abstract » doi: 10.24911/IJMDC.51-1545817090
    Cited : 3 times [Click to see citing articles]

  • Awareness of the Saudi population about the role of the Emergency Rooms
    Zead Ibrahim A. Alhussain, Mohammed Ali A. Alghamdi, Rana Mohamed Ahmed, Abdullah Yahya Aldhban, Abdulrahman Ali Alghamdi, Naif Shalan J. Alalyani
    IJMDC. 2019; 3(11): 957-962
    » Abstract » doi: 10.24911/IJMDC.51-1568717752
    Cited : 3 times [Click to see citing articles]

    •

    About International Journal of Medicine in Developing Countries

    International Journal of Medicine in Developing Countries is a peer-reviewed, open-access international medical journal. Journal Title Internat ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Publisher: Waraqa Publishing House, Riyadh, Saudi Arabia



    Hosted by: Discover STM Publishing Ltd. 164 Moyville. Rathfarnham, Dublin, D16Y4E, Ireland.

    Hours:  M-F: 7:30am - 4:30pm 



    Emails:

    Journal Editorial Office:  contact@ijmdc.com

    All queries regarding the publishing or acceptance of the manuscript should be directed to the Journal Editorial Office at Riyadh, Saudi Arabia. 

    Hosting service is provided by Discover STM (Ireland):  contact@discoverpublish.com
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    Author LoginReviewer LoginAbout PublisherEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessAuthor's Rights and ObligationsPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesAdvertising PolicyLicense InformationCopyright Information