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2026, Vol: 10, Issue: 3
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Review Article
Online Published: 21 Jan 2026
 


Safety and efficacy of ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease: a systematic review and meta-analysis

Khaled Ali Alenazi, Shahad Adel Alhemaid, Danah Zaki Al Abbas, Ali Ayad Alobaidi, Meshari Khalaf Alghuraibi, Rana Alqarni, Shahad Hammad, Reham F. Aldirhami, Norah Abdullah Alharthi, Mohamed Hammed Alyoubi, Ameen Alyoubi, Leena Almobty.


Abstract
Iron deficiency anemia (IDA) is a prevalent and challenging complication among individuals with inflammatory bowel disease (IBD), greatly influencing their quality of life and the management of their condition. Ferric carboxymaltose (FCM) has surfaced as an effective therapeutic alternative, providing enhanced safety and tolerance in comparison to oral iron treatments and other intravenous options. Although current research has highlighted the promising benefits of FCM, there is still a need for a systematic review that consolidated data from randomized controlled trials (RCTs) to offer a more precise and comprehensive understanding of its relative efficacy and safety. This study aimed to evaluate the safety and efficacy of FCM among adult patients with IDA related to IBD. Furthermore, the hematological outcomes and the tolerance of patients receiving FCM were compared to other oral iron formulations, intravenous iron formulations, and placebo. Five RCTs (n = 1,007) met the inclusion criteria. Pooled analysis showed that FCM significantly increased hemoglobin (+2.94 g/dL; 95% CI 2.14–3.74; p<0.00001) and ferritin (+232 µg/L; 95% CI 34.85–429.63; p-value=0.02). The pooled incidence of treatment-emergent adverse events (TEAEs) was 28% (95% CI 0.11–0.45), with no significant difference compared to oral iron (OR = 0.77; p = 0.59). Most TEAEs were mild to moderate, and no FCM-related deaths occurred. In conclusion, Ferric carboxymaltose is a safe and effective intravenous therapy for the rapid correction of IDA in IBD. It offers superior hematologic improvement, with excellent tolerability, supporting its role as a preferred first-line parenteral iron formulation in this patient population.

Key words: Ferric carboxymaltose, iron deficiency anemia, inflammatory bowel disease, crohn's disease, ulcerative colitis, systematic review, meta-analysis


 
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How to Cite this Article
Pubmed Style

Alenazi KA, Alhemaid SA, Abbas DZA, Alobaidi AA, Alghuraibi MK, Alqarni R, Hammad S, Aldirhami RF, Alharthi NA, Alyoubi MH, Alyoubi A, Almobty L. Safety and efficacy of ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease: a systematic review and meta-analysis. IJMDC. 2026; 10(3): 950-968. doi:10.24911/IJMDC.51-1764689048

Web Style

Alenazi KA, Alhemaid SA, Abbas DZA, Alobaidi AA, Alghuraibi MK, Alqarni R, Hammad S, Aldirhami RF, Alharthi NA, Alyoubi MH, Alyoubi A, Almobty L. Safety and efficacy of ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease: a systematic review and meta-analysis. https://www.ijmdc.com/?mno=300997 [Access: February 23, 2026]. doi:10.24911/IJMDC.51-1764689048

AMA (American Medical Association) Style

Alenazi KA, Alhemaid SA, Abbas DZA, Alobaidi AA, Alghuraibi MK, Alqarni R, Hammad S, Aldirhami RF, Alharthi NA, Alyoubi MH, Alyoubi A, Almobty L. Safety and efficacy of ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease: a systematic review and meta-analysis. IJMDC. 2026; 10(3): 950-968. doi:10.24911/IJMDC.51-1764689048


Vancouver/ICMJE Style

Alenazi KA, Alhemaid SA, Abbas DZA, Alobaidi AA, Alghuraibi MK, Alqarni R, Hammad S, Aldirhami RF, Alharthi NA, Alyoubi MH, Alyoubi A, Almobty L. Safety and efficacy of ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease: a systematic review and meta-analysis. IJMDC. (2026), [cited February 23, 2026]; 10(3): 950-968. doi:10.24911/IJMDC.51-1764689048


Harvard Style

Alenazi, K. A., Alhemaid, . S. A., Abbas, . D. Z. A., Alobaidi, . A. A., Alghuraibi, . M. K., Alqarni, . R., Hammad, . S., Aldirhami, . R. F., Alharthi, . N. A., Alyoubi, . M. H., Alyoubi, . A. & Almobty, . L. (2026) Safety and efficacy of ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease: a systematic review and meta-analysis. IJMDC, 10 (3), 950-968. doi:10.24911/IJMDC.51-1764689048


Turabian Style

Alenazi, Khaled Ali, Shahad Adel Alhemaid, Danah Zaki Al Abbas, Ali Ayad Alobaidi, Meshari Khalaf Alghuraibi, Rana Alqarni, Shahad Hammad, Reham F. Aldirhami, Norah Abdullah Alharthi, Mohamed Hammed Alyoubi, Ameen Alyoubi, and Leena Almobty. 2026. Safety and efficacy of ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 10 (3), 950-968. doi:10.24911/IJMDC.51-1764689048


Chicago Style

Alenazi, Khaled Ali, Shahad Adel Alhemaid, Danah Zaki Al Abbas, Ali Ayad Alobaidi, Meshari Khalaf Alghuraibi, Rana Alqarni, Shahad Hammad, Reham F. Aldirhami, Norah Abdullah Alharthi, Mohamed Hammed Alyoubi, Ameen Alyoubi, and Leena Almobty. "Safety and efficacy of ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 10 (2026), 950-968. doi:10.24911/IJMDC.51-1764689048


MLA (The Modern Language Association) Style

Alenazi, Khaled Ali, Shahad Adel Alhemaid, Danah Zaki Al Abbas, Ali Ayad Alobaidi, Meshari Khalaf Alghuraibi, Rana Alqarni, Shahad Hammad, Reham F. Aldirhami, Norah Abdullah Alharthi, Mohamed Hammed Alyoubi, Ameen Alyoubi, and Leena Almobty. "Safety and efficacy of ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 10.3 (2026), 950-968. Print. doi:10.24911/IJMDC.51-1764689048


APA (American Psychological Association) Style

Alenazi, K. A., Alhemaid, . S. A., Abbas, . D. Z. A., Alobaidi, . A. A., Alghuraibi, . M. K., Alqarni, . R., Hammad, . S., Aldirhami, . R. F., Alharthi, . N. A., Alyoubi, . M. H., Alyoubi, . A. & Almobty, . L. (2026) Safety and efficacy of ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 10 (3), 950-968. doi:10.24911/IJMDC.51-1764689048




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