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2026, Vol: 10, Issue: 3
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Review Article
Online Published: 22 Jan 2026
 


Efficacy and safety of ciprofol versus propofol for sedation in hysteroscopy: a systematic review and meta-analysis

Azzam Ahmad Alghamdi, Taif Khaled Hakami, Roa’a Abdu Jubran, Mohamed Youssry Fawzy Youssef, Shahd Ali Halwani, Abdulaziz Fahad Mohammed Alhasani, Ghala Fahad Alzahrani, Zainab Fadhel Alshulah, Shahad Bader Alaql, Mostafa Habeeb Alhodibi.


Abstract
Ciprofol and propofol are two intravenous anesthetics that are used for procedure sedation and have different pharmacological characteristics. Hysteroscopy is a gentle, non-invasive gynecological operation that requires proper and safe anesthesia to ensure a patient's comfort and the success of the operation. This meta-analysis and systematic review evaluated the efficacy and safety of ciprofol against propofol sedation for hysteroscopy. An intensive search of PubMed, Scopus, Web of Science, and the Cochrane Library yielded randomized controlled trials comparing the two agents. Random-effects models were used to evaluate five studies (a total of 1718 patients). The ciprofol was linked to a significantly lower frequency of respiratory depression, hypoxemia (RR = 0.34, 95% CI 0.25-0.46), hypotension (RR = 0.58, 95% CI 0.50-0.67), and injection discomfort (RR = 0.15, 95% CI 0.06-0.36) with a high level of statistical significance. There was a slight reduction in the heart rate in the ciprofloxacin group five minutes after induction, and mean arterial pressure was significantly raised after sensitivity analysis. The sedative success rates of propofol and ciprofol did not differ significantly. In general, the evidence suggested that ciprofol is just as effective and had a better safety profile than propofol in the hysteroscopy sedation context and is therefore a promising candidate to improve safety and patient outcomes of the procedure.

Key words: Ciprofol, propofol, hysteroscopy, sedation, systematic review, meta-analysis.


 
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How to Cite this Article
Pubmed Style

Alghamdi AA, Hakami TK, Jubran RA, Youssef MYF, Halwani SA, Alhasani AFM, Alzahrani GF, Alshulah ZF, Alaql SB, Alhodibi MH. Efficacy and safety of ciprofol versus propofol for sedation in hysteroscopy: a systematic review and meta-analysis. IJMDC. 2026; 10(3): 969-977. doi:10.24911/IJMDC.51-1765577735

Web Style

Alghamdi AA, Hakami TK, Jubran RA, Youssef MYF, Halwani SA, Alhasani AFM, Alzahrani GF, Alshulah ZF, Alaql SB, Alhodibi MH. Efficacy and safety of ciprofol versus propofol for sedation in hysteroscopy: a systematic review and meta-analysis. https://www.ijmdc.com/?mno=303040 [Access: February 23, 2026]. doi:10.24911/IJMDC.51-1765577735

AMA (American Medical Association) Style

Alghamdi AA, Hakami TK, Jubran RA, Youssef MYF, Halwani SA, Alhasani AFM, Alzahrani GF, Alshulah ZF, Alaql SB, Alhodibi MH. Efficacy and safety of ciprofol versus propofol for sedation in hysteroscopy: a systematic review and meta-analysis. IJMDC. 2026; 10(3): 969-977. doi:10.24911/IJMDC.51-1765577735


Vancouver/ICMJE Style

Alghamdi AA, Hakami TK, Jubran RA, Youssef MYF, Halwani SA, Alhasani AFM, Alzahrani GF, Alshulah ZF, Alaql SB, Alhodibi MH. Efficacy and safety of ciprofol versus propofol for sedation in hysteroscopy: a systematic review and meta-analysis. IJMDC. (2026), [cited February 23, 2026]; 10(3): 969-977. doi:10.24911/IJMDC.51-1765577735


Harvard Style

Alghamdi, A. A., Hakami, . T. K., Jubran, . R. A., Youssef, . M. Y. F., Halwani, . S. A., Alhasani, . A. F. M., Alzahrani, . G. F., Alshulah, . Z. F., Alaql, . S. B. & Alhodibi, . M. H. (2026) Efficacy and safety of ciprofol versus propofol for sedation in hysteroscopy: a systematic review and meta-analysis. IJMDC, 10 (3), 969-977. doi:10.24911/IJMDC.51-1765577735


Turabian Style

Alghamdi, Azzam Ahmad, Taif Khaled Hakami, Roa'a Abdu Jubran, Mohamed Youssry Fawzy Youssef, Shahd Ali Halwani, Abdulaziz Fahad Mohammed Alhasani, Ghala Fahad Alzahrani, Zainab Fadhel Alshulah, Shahad Bader Alaql, and Mostafa Habeeb Alhodibi. 2026. Efficacy and safety of ciprofol versus propofol for sedation in hysteroscopy: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 10 (3), 969-977. doi:10.24911/IJMDC.51-1765577735


Chicago Style

Alghamdi, Azzam Ahmad, Taif Khaled Hakami, Roa'a Abdu Jubran, Mohamed Youssry Fawzy Youssef, Shahd Ali Halwani, Abdulaziz Fahad Mohammed Alhasani, Ghala Fahad Alzahrani, Zainab Fadhel Alshulah, Shahad Bader Alaql, and Mostafa Habeeb Alhodibi. "Efficacy and safety of ciprofol versus propofol for sedation in hysteroscopy: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 10 (2026), 969-977. doi:10.24911/IJMDC.51-1765577735


MLA (The Modern Language Association) Style

Alghamdi, Azzam Ahmad, Taif Khaled Hakami, Roa'a Abdu Jubran, Mohamed Youssry Fawzy Youssef, Shahd Ali Halwani, Abdulaziz Fahad Mohammed Alhasani, Ghala Fahad Alzahrani, Zainab Fadhel Alshulah, Shahad Bader Alaql, and Mostafa Habeeb Alhodibi. "Efficacy and safety of ciprofol versus propofol for sedation in hysteroscopy: a systematic review and meta-analysis." International Journal of Medicine in Developing Countries 10.3 (2026), 969-977. Print. doi:10.24911/IJMDC.51-1765577735


APA (American Psychological Association) Style

Alghamdi, A. A., Hakami, . T. K., Jubran, . R. A., Youssef, . M. Y. F., Halwani, . S. A., Alhasani, . A. F. M., Alzahrani, . G. F., Alshulah, . Z. F., Alaql, . S. B. & Alhodibi, . M. H. (2026) Efficacy and safety of ciprofol versus propofol for sedation in hysteroscopy: a systematic review and meta-analysis. International Journal of Medicine in Developing Countries, 10 (3), 969-977. doi:10.24911/IJMDC.51-1765577735




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