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2026, Vol: 10, Issue: 8
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Original Article
Online Published: 16 Aug 2026
 


Beyond clinical suspicion: the crucial role of histological confirmation in pyogenic granuloma diagnosis

Shaikah Al-aojan, Lena Defallah G Alzahrani, Rahaf Alshareef, Nasser Almulhim, Luluah Al-mubarak.


Abstract
Abstract

Background and Aim
Pyogenic granuloma (PG) is a common acquired benign vascular neoplasm that presents as a rapidly growing red nodule. Several conditions can mimic PG clinically leading to misdiagnosis and inappropriate treatment. Our study aims to characterize the distinguishing features between PG and non-PG lesions and to evaluate the prevalence of PG misdiagnosis.

Methods:
A retrospective analysis, using histopathology reports from patients clinically diagnosed with PG between 2018 - 2024. Statistical analysis was performed using STATA software, employing both Chi-squared and Fisher's exact tests to evaluate significant associations.

Results:
A total of 47 cases were analyzed. Among the 47 clinically diagnosed PG cases, 22 (46.8%) were reclassified as non-PG upon histopathological evaluation. The most common misdiagnoses were non-melanoma skin cancers (13%), followed by vascular neoplasms (11%). PG cases showed significant association with bleeding tendency (84% of PG cases vs. 50% of non-PG cases), while ulceration was more prevalent in non-PG lesions (12% of PG cases vs. 50% of non-PG cases).

Conclusion:
Our findings suggest that older age, longer lesion duration, absence of bleeding, and the presence of ulceration are key clinical features predictive of non-PG cases.

Key words: Histopathology; Lobular capillary hemangioma; Pyogenic granuloma; Skin cancer; Vascular neoplasm


 
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How to Cite this Article
Pubmed Style

Al-aojan S, Alzahrani LDG, Alshareef R, Almulhim N, Al-mubarak L. Beyond clinical suspicion: the crucial role of histological confirmation in pyogenic granuloma diagnosis. IJMDC. Online First: 16 Aug, 2026. doi:10.24911/IJMDC.51-1783880788

Web Style

Al-aojan S, Alzahrani LDG, Alshareef R, Almulhim N, Al-mubarak L. Beyond clinical suspicion: the crucial role of histological confirmation in pyogenic granuloma diagnosis. https://www.ijmdc.com/?mno=327568 [Access: August 16, 2026]. doi:10.24911/IJMDC.51-1783880788

AMA (American Medical Association) Style

Al-aojan S, Alzahrani LDG, Alshareef R, Almulhim N, Al-mubarak L. Beyond clinical suspicion: the crucial role of histological confirmation in pyogenic granuloma diagnosis. IJMDC. Online First: 16 Aug, 2026. doi:10.24911/IJMDC.51-1783880788


Vancouver/ICMJE Style

Al-aojan S, Alzahrani LDG, Alshareef R, Almulhim N, Al-mubarak L. Beyond clinical suspicion: the crucial role of histological confirmation in pyogenic granuloma diagnosis. IJMDC, [cited August 16, 2026]; Online First: 16 Aug, 2026. doi:10.24911/IJMDC.51-1783880788


Harvard Style

Al-aojan, S., Alzahrani, . L. D. G., Alshareef, . R., Almulhim, . N. & Al-mubarak, . L. (0) Beyond clinical suspicion: the crucial role of histological confirmation in pyogenic granuloma diagnosis. IJMDC, Online First: 16 Aug, 2026. doi:10.24911/IJMDC.51-1783880788


Turabian Style

Al-aojan, Shaikah, Lena Defallah G Alzahrani, Rahaf Alshareef, Nasser Almulhim, and Luluah Al-mubarak. 0. Beyond clinical suspicion: the crucial role of histological confirmation in pyogenic granuloma diagnosis. International Journal of Medicine in Developing Countries, Online First: 16 Aug, 2026. doi:10.24911/IJMDC.51-1783880788


Chicago Style

Al-aojan, Shaikah, Lena Defallah G Alzahrani, Rahaf Alshareef, Nasser Almulhim, and Luluah Al-mubarak. "Beyond clinical suspicion: the crucial role of histological confirmation in pyogenic granuloma diagnosis." International Journal of Medicine in Developing Countries Online First: 16 Aug, 2026. doi:10.24911/IJMDC.51-1783880788


MLA (The Modern Language Association) Style

Al-aojan, Shaikah, Lena Defallah G Alzahrani, Rahaf Alshareef, Nasser Almulhim, and Luluah Al-mubarak. "Beyond clinical suspicion: the crucial role of histological confirmation in pyogenic granuloma diagnosis." International Journal of Medicine in Developing Countries Online First: 16 Aug, 2026. Web. 16 Aug 2026 doi:10.24911/IJMDC.51-1783880788


APA (American Psychological Association) Style

Al-aojan, S., Alzahrani, . L. D. G., Alshareef, . R., Almulhim, . N. & Al-mubarak, . L. (0) Beyond clinical suspicion: the crucial role of histological confirmation in pyogenic granuloma diagnosis. International Journal of Medicine in Developing Countries, Online First: 16 Aug, 2026. doi:10.24911/IJMDC.51-1783880788




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