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2026, Vol: 10, Issue: 9
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Review Article
Online Published: 09 Oct 2026
 


Global Research Landscape of Diabetes Mellitus Type 2 in the SGLT2 Inhibitors and GLP-1 Receptor Agonists Era: A Bibliometric Analysis of The Top 1000 Publications

Abdulrahman Alobaid, Fahd Aljohani, Faisal Alsolami, Leena Alamri, Abdulbasit Bugis, Aryam Aljohani, Rahaf Alamri, Najwan Abuaba, Badr Mohammed Madani.


Abstract
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have transformed the management of type 2 diabetes mellitus (T2DM), extending treatment goals beyond glycemic control to encompass cardiovascular, renal, and weight-related outcomes. Despite the rapid expansion of this literature, no comprehensive bibliometric analysis has mapped the global research landscape spanning both drug classes together. This study analyzed the 1,000 most-cited publications on SGLT2i and GLP-1 RAs in T2DM management, indexed in the Web of Science Core Collection between 2015 and 2025, using Microsoft Excel for descriptive analysis and VOSviewer for network visualization. The dataset accrued 146,574 citations, with annual output rising from 89 publications in 2015 to a peak of 130 in 2019 before plateauing and declining toward 2025. The United States (n = 349), United Kingdom (n = 225), and Denmark (n = 172) led global contribution under full counting, with research activity concentrated among a small number of high-income countries. Diabetes, Obesity & Metabolism was the leading journal (n = 142), Novo Nordisk the most productive institution (n = 115), and Hiddo J. L. Heerspink the most prolific author (n = 31). The most-cited publication was the LEADER trial (6,923 citations). Keyword co-occurrence analysis identified three major thematic clusters: GLP-1 RAs and weight management, SGLT2i therapy, and cardiovascular outcomes, with temporal overlay analysis revealing a shift toward obesity- and weight-centric themes in more recent literature. These findings characterized a scientifically mature but geographically concentrated research field, highlighting priorities for future research in global equity and real-world implementation.

Key words: SGLT2 inhibitors, GLP-1 receptor agonists, Type 2 diabetes mellitus, bibliometric analysis, cardiometabolic outcomes


 
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How to Cite this Article
Pubmed Style

Alobaid A, Aljohani F, Alsolami F, Alamri L, Bugis A, Aljohani A, Alamri R, Abuaba N, Madani BM. Global Research Landscape of Diabetes Mellitus Type 2 in the SGLT2 Inhibitors and GLP-1 Receptor Agonists Era: A Bibliometric Analysis of The Top 1000 Publications. IJMDC. Online First: 09 Oct, 2026. doi:10.24911/IJMDC.51-1786306992

Web Style

Alobaid A, Aljohani F, Alsolami F, Alamri L, Bugis A, Aljohani A, Alamri R, Abuaba N, Madani BM. Global Research Landscape of Diabetes Mellitus Type 2 in the SGLT2 Inhibitors and GLP-1 Receptor Agonists Era: A Bibliometric Analysis of The Top 1000 Publications. https://www.ijmdc.com/?mno=330753 [Access: October 09, 2026]. doi:10.24911/IJMDC.51-1786306992

AMA (American Medical Association) Style

Alobaid A, Aljohani F, Alsolami F, Alamri L, Bugis A, Aljohani A, Alamri R, Abuaba N, Madani BM. Global Research Landscape of Diabetes Mellitus Type 2 in the SGLT2 Inhibitors and GLP-1 Receptor Agonists Era: A Bibliometric Analysis of The Top 1000 Publications. IJMDC. Online First: 09 Oct, 2026. doi:10.24911/IJMDC.51-1786306992


Vancouver/ICMJE Style

Alobaid A, Aljohani F, Alsolami F, Alamri L, Bugis A, Aljohani A, Alamri R, Abuaba N, Madani BM. Global Research Landscape of Diabetes Mellitus Type 2 in the SGLT2 Inhibitors and GLP-1 Receptor Agonists Era: A Bibliometric Analysis of The Top 1000 Publications. IJMDC, [cited October 09, 2026]; Online First: 09 Oct, 2026. doi:10.24911/IJMDC.51-1786306992


Harvard Style

Alobaid, A., Aljohani, . F., Alsolami, . F., Alamri, . L., Bugis, . A., Aljohani, . A., Alamri, . R., Abuaba, . N. & Madani, . B. M. (2026) Global Research Landscape of Diabetes Mellitus Type 2 in the SGLT2 Inhibitors and GLP-1 Receptor Agonists Era: A Bibliometric Analysis of The Top 1000 Publications. IJMDC, Online First: 09 Oct, 2026. doi:10.24911/IJMDC.51-1786306992


Turabian Style

Alobaid, Abdulrahman, Fahd Aljohani, Faisal Alsolami, Leena Alamri, Abdulbasit Bugis, Aryam Aljohani, Rahaf Alamri, Najwan Abuaba, and Badr Mohammed Madani. 2026. Global Research Landscape of Diabetes Mellitus Type 2 in the SGLT2 Inhibitors and GLP-1 Receptor Agonists Era: A Bibliometric Analysis of The Top 1000 Publications. International Journal of Medicine in Developing Countries, Online First: 09 Oct, 2026. doi:10.24911/IJMDC.51-1786306992


Chicago Style

Alobaid, Abdulrahman, Fahd Aljohani, Faisal Alsolami, Leena Alamri, Abdulbasit Bugis, Aryam Aljohani, Rahaf Alamri, Najwan Abuaba, and Badr Mohammed Madani. "Global Research Landscape of Diabetes Mellitus Type 2 in the SGLT2 Inhibitors and GLP-1 Receptor Agonists Era: A Bibliometric Analysis of The Top 1000 Publications." International Journal of Medicine in Developing Countries Online First: 09 Oct, 2026. doi:10.24911/IJMDC.51-1786306992


MLA (The Modern Language Association) Style

Alobaid, Abdulrahman, Fahd Aljohani, Faisal Alsolami, Leena Alamri, Abdulbasit Bugis, Aryam Aljohani, Rahaf Alamri, Najwan Abuaba, and Badr Mohammed Madani. "Global Research Landscape of Diabetes Mellitus Type 2 in the SGLT2 Inhibitors and GLP-1 Receptor Agonists Era: A Bibliometric Analysis of The Top 1000 Publications." International Journal of Medicine in Developing Countries Online First: 09 Oct, 2026. Web. 09 Oct 2026 doi:10.24911/IJMDC.51-1786306992


APA (American Psychological Association) Style

Alobaid, A., Aljohani, . F., Alsolami, . F., Alamri, . L., Bugis, . A., Aljohani, . A., Alamri, . R., Abuaba, . N. & Madani, . B. M. (2026) Global Research Landscape of Diabetes Mellitus Type 2 in the SGLT2 Inhibitors and GLP-1 Receptor Agonists Era: A Bibliometric Analysis of The Top 1000 Publications. International Journal of Medicine in Developing Countries, Online First: 09 Oct, 2026. doi:10.24911/IJMDC.51-1786306992




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