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Original Article
Online Published: 05 Oct 2025
 


Impact of vitamin D on skin aging and age-related dermatological conditions

Muhannad M Alwadany, Saleha A Aldawsari, Turki H Albinhar, Fajr Saad Alkhalifa, Feras M Alwadany, Fisal M Alwadany, Rakan F Alwadany.


Abstract
As a fat-soluble micronutrient, vitamin D is essential for healthy skin because it affects keratinocyte differentiation, immune function, and extracellular matrix integrity. Skin aging is driven by both intrinsic factors, such as cellular senescence and oxidative stress, and extrinsic factors, particularly ultraviolet (UV) radiation. This review explores the impact of vitamin D on skin aging and age-related dermatological conditions, emphasizing its preventive and therapeutic roles. The relevant research articles were searched by using databases like PubMed, Google Scholar, and Elsevier. The keywords that we used in the search strategy included “vitamin D,” “skin aging,” “photoaging,” “antioxidant properties of vitamin D,” “anti-inflammatory effects of vitamin D,” and “skin aging.” Through this search, 31 article were included that were published between the years 2016 and 2024. Vitamin D possesses potent antioxidant and anti-inflammatory effects, upregulating antioxidative enzymes and regulating nuclear factor erythroid 2 (related factor) 2 (Nrf2) signaling to ameliorate oxidative damage. It also improves DNA repair mechanisms and thereby reduces UV-induced mutations and cellular apoptosis. Vitamin D deficiency appears to modulate the clinical course and immune pathways of various skin diseases, including psoriasis, atopic dermatitis, vitiligo, alopecia areata, seborrheic dermatitis, and rosacea. There have been several clinical studies of vitamin D for the role of correcting these conditions in reducing the severity of disease and improving skin barrier function. Accordingly, oral vitamin D increases systemic levels of vitamin D, while topical formulations such as calcipotriol and calcitriol lysate skin keratinocyte proliferation and inflammation.

Key words: Impact, vitamin D, skin aging, dermatological conditions, review


 
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How to Cite this Article
Pubmed Style

Alwadany MM, Aldawsari SA, Albinhar TH, Alkhalifa FS, Alwadany FM, Alwadany FM, Alwadany RF. Impact of vitamin D on skin aging and age-related dermatological conditions. IJMDC. Online First: 05 Oct, 2025. doi:10.24911/IJMDC.51-1751541494

Web Style

Alwadany MM, Aldawsari SA, Albinhar TH, Alkhalifa FS, Alwadany FM, Alwadany FM, Alwadany RF. Impact of vitamin D on skin aging and age-related dermatological conditions. https://www.ijmdc.com/?mno=268644 [Access: October 13, 2025]. doi:10.24911/IJMDC.51-1751541494

AMA (American Medical Association) Style

Alwadany MM, Aldawsari SA, Albinhar TH, Alkhalifa FS, Alwadany FM, Alwadany FM, Alwadany RF. Impact of vitamin D on skin aging and age-related dermatological conditions. IJMDC. Online First: 05 Oct, 2025. doi:10.24911/IJMDC.51-1751541494


Vancouver/ICMJE Style

Alwadany MM, Aldawsari SA, Albinhar TH, Alkhalifa FS, Alwadany FM, Alwadany FM, Alwadany RF. Impact of vitamin D on skin aging and age-related dermatological conditions. IJMDC, [cited October 13, 2025]; Online First: 05 Oct, 2025. doi:10.24911/IJMDC.51-1751541494


Harvard Style

Alwadany, M. M., Aldawsari, . S. A., Albinhar, . T. H., Alkhalifa, . F. S., Alwadany, . F. M., Alwadany, . F. M. & Alwadany, . R. F. (2025) Impact of vitamin D on skin aging and age-related dermatological conditions. IJMDC, Online First: 05 Oct, 2025. doi:10.24911/IJMDC.51-1751541494


Turabian Style

Alwadany, Muhannad M, Saleha A Aldawsari, Turki H Albinhar, Fajr Saad Alkhalifa, Feras M Alwadany, Fisal M Alwadany, and Rakan F Alwadany. 2025. Impact of vitamin D on skin aging and age-related dermatological conditions. International Journal of Medicine in Developing Countries, Online First: 05 Oct, 2025. doi:10.24911/IJMDC.51-1751541494


Chicago Style

Alwadany, Muhannad M, Saleha A Aldawsari, Turki H Albinhar, Fajr Saad Alkhalifa, Feras M Alwadany, Fisal M Alwadany, and Rakan F Alwadany. "Impact of vitamin D on skin aging and age-related dermatological conditions." International Journal of Medicine in Developing Countries Online First: 05 Oct, 2025. doi:10.24911/IJMDC.51-1751541494


MLA (The Modern Language Association) Style

Alwadany, Muhannad M, Saleha A Aldawsari, Turki H Albinhar, Fajr Saad Alkhalifa, Feras M Alwadany, Fisal M Alwadany, and Rakan F Alwadany. "Impact of vitamin D on skin aging and age-related dermatological conditions." International Journal of Medicine in Developing Countries Online First: 05 Oct, 2025. Web. 13 Oct 2025 doi:10.24911/IJMDC.51-1751541494


APA (American Psychological Association) Style

Alwadany, M. M., Aldawsari, . S. A., Albinhar, . T. H., Alkhalifa, . F. S., Alwadany, . F. M., Alwadany, . F. M. & Alwadany, . R. F. (2025) Impact of vitamin D on skin aging and age-related dermatological conditions. International Journal of Medicine in Developing Countries, Online First: 05 Oct, 2025. doi:10.24911/IJMDC.51-1751541494




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